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Stevioside is a natural non-caloric sweetener extracted from Stevia rebaudiana (Bertoni) leaves. It has been widely used in many countries, including Japan, Korea, China, Brazil and Paraguay, either as a substitute for sucrose in beverages and foods or as a household sweetener. The aim of this work was to study its genotoxic potentiality in eukaryotic cells. Wistar rats were treated with stevioside solution (4mg/mL) through oral administration (ad libitum) and the DNA-induced damage was evaluated using the single cell gel electrophoresis (comet assay). The results showed that treatment with stevioside generates lesions in peripheral blood, liver, brain and spleen cells in different levels, the largest effect being in liver. Therefore, these undesired effects must be better understood, once the data present here point to possible stevioside mutagenic properties.
Food Chem Toxicol. 2007. Apr;45(4):662-6.
Analysis of genotoxic potentiality of stevioside by comet assay.
Nunes AP, Ferreira-Machado SC, Nunes RM, Dantas FJ, De Mattos JC, Caldeira-de-Ara?jo A.
Departamento de Biof?sica e Biometria, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Av 28 de Setembro, 87, 20551-030 Rio de Janeiro, RJ, Brazil.
A study conducted on prepubertal male rats showed that chronic administration (60 days) of a Stevia rebaudiana aqueous extract produced a decrease in final weight of testis, seminal vesicle and cauda epididymidis. In addition, the fructose content of the accessory coïtus glands and the epididymal sperm concentration are decreased. Stevia treatment tended to decrease the plasma testosterone level, probably by a putative affinity of glycosides of extract for a certain androgen receptor, and no alteration occurred in luteinizing hormone level. These data are consistent with the possibility that Stevia extracts may decrease the fertility of male rats.
J Ethnopharmacol. 1999 Nov 1;67(2):157-61.
Effects of chronic administration of Stevia rebaudiana on fertility in rats.
Melis MS.
Source
Departamento de Biologia, Setor de Fisiologia, Faculdade de Filosofia, Ciências e Letras, Universidade de São Paulo, Ribeirão Preto, Brazil. msmelis@ffclrp.usp.br
Abstract
Food Chem Toxicol. 2007. Apr;45(4):662-6.
Analysis of genotoxic potentiality of stevioside by comet assay.
Nunes AP, Ferreira-Machado SC, Nunes RM, Dantas FJ, De Mattos JC, Caldeira-de-Ara?jo A.
Departamento de Biof?sica e Biometria, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Av 28 de Setembro, 87, 20551-030 Rio de Janeiro, RJ, Brazil.
A study conducted on prepubertal male rats showed that chronic administration (60 days) of a Stevia rebaudiana aqueous extract produced a decrease in final weight of testis, seminal vesicle and cauda epididymidis. In addition, the fructose content of the accessory coïtus glands and the epididymal sperm concentration are decreased. Stevia treatment tended to decrease the plasma testosterone level, probably by a putative affinity of glycosides of extract for a certain androgen receptor, and no alteration occurred in luteinizing hormone level. These data are consistent with the possibility that Stevia extracts may decrease the fertility of male rats.
J Ethnopharmacol. 1999 Nov 1;67(2):157-61.
Effects of chronic administration of Stevia rebaudiana on fertility in rats.
Melis MS.
Source
Departamento de Biologia, Setor de Fisiologia, Faculdade de Filosofia, Ciências e Letras, Universidade de São Paulo, Ribeirão Preto, Brazil. msmelis@ffclrp.usp.br
Abstract