5-HTP , wie gebruikt t?

[Worstebroodje]

Wie gebruikt het dus, of heeft er ervaring mee? Ik zat er dus over na te denken om het eens een keertje te bestellen, maar ik twijfel nog een beetje...

Kwam laatst op Fok! namelijk een stuk tegen van een user dat het namelijk bullshit zou zijn:

Ik heb het uit de Life Extension Foundation newsletter.

quote:
All this would be merely humorous (caveat emptor) were it not for some other facts. At worst, ignorant people fooling with 5-HTP actually risk their health, since serotonin in the peripheral blood is not benign. Serotonin causes not only harmless flushing and diarrhea, but people with serotonin secreting tumors (hindgut carcinoids) also have problems with fibrosis of the endocardium and valves in their right hearts, which can cause heart failure. This fibrosis is caused by the serotonin. This effect can also be seen with dietary intake of only modest amounts of serotonin, and there has actually been described in the medical literature a tribe of South Sea islanders with right heart fibrosis as a result of eating green banana mash (matuki), which poisons them with its serotonin content. No, I'm not making this up. The hydroxylation of tryptophan is a rate-limiting step in the peripheral production of serotonin, and one bypasses it at one's peril.

How much does it take? Several hundred milligrams of 5-HTP taken per day, if converted to serotonin, would result in a urinary excretion of the serotonin metabolite 5-hydroxyindoleac-etic acid (5-HIAA) of several hundred milligrams also-- an amount well within the urinary excretion range of the average person with a serotonin producing carcinoid. Such a dose of 5-HTP certainly would result in a serotonin blood load comparable to that of green-banana-diet eating people who have serotonin-induced heart valve disease. Normally, people do not excrete breakdown products of more than 10 mg of serotonin metabolites per day. If you take one capsule per day of 50 mg 5-HTP with 10 mg B6, however, you would be expected to go to at least 50 mg per day of 5-HIAA in the urine. Less metabolism in the liver (less B6) would result in less 5-HIAA in the urine. If you are going to take 5-HTP, therefore, you probably need 5-HIAA urine monitoring, to figure out just how big a dose of systemic serotonin you're actually getting (and incidentally, how much 5-HTP you're wasting). See a doctor!

De verkoop van 5-HTP zou verboden moeten worden. Het begint zich in je maag al gedeeltelijk om te zetten in serotonine, en van de rest wordt 80% in je lever omgezet in serotonine.

Dat klinkt leuk, maar serotonine kan van buiten je hersenen de blood-brain-barrier niet door en komt nooit aan. Het blijft dus nutteloos in je bloed zitten en verdoet vervolgens je hart, bloedvaten, lever en nieren (vrij snel zelfs).

Je kan beter l-tryptofaan nemen, de 'vertraging' door de extra stap l-tryptofaan -> 5-HTP -> serotonine is een natuurlijk mechanisme om je lichaam te beschermen tegen schade aan je organen door teveel serotonine.

 

[Marter]

5-Hydroxy-L-tryptophan (5-HTP) is the immediate precursor in the biosynthesis of 5-hydroxy-tryptamine (5-HT; serotonin) from the essential amino acid L-tryptophan (L-Trp). The use of L-Trp as a dietary supplement was discontinued in 1989 due to an outbreak of eosinophilia-myalgia syndrome (EMS) that was traced to a contaminated synthetic L-Trp from a single manufacturer. 5-HTP has since become a popular dietary supplement in lieu of the removal of L-Trp from the market. Because of its chemical and biochemical relationship to L-Trp, 5-HTP has been under vigilance by consumers, industry, academia and government for its safety. However, no definitive cases of toxicity have emerged despite the worldwide usage of 5-HTP for last 20 years, with the possible exception of one unresolved case of a Canadian woman. Extensive analyses of several sources of 5-HTP have shown no toxic contaminants similar to those associated with L-Trp, nor the presence of any other significant impurities. A minor chromatographic peak (peak X) reported in some 5-HTP samples lacks credibility due to chromatographic artifacts and infinitesimal concentrations, and has raised undue speculations concerning its chemistry and toxicity

bron
Dus niet echt om je zorgen over te maken.

En dat 5-HTP je hersennen bereikt is geweten.

OBJECTIVE: To review the literature regarding the effectiveness of 5-hydroxytryptophan (5-HT) and L-tryptophan in the treatment of unipolar depression. METHODS: A systematic review of the literature from 1966 to 2000 using the search terms 'tryptophan', 5-hydroxytryptophan', '5-HTP', '5-HT' and 'depression'. We extracted and grouped data for meta-analysis by pooling odds ratios (OR) and relative risks where possible. RESULTS: One hundred and eight studies were located of which only two studies, one of 5-HT and one of L-tryptophan, with a total of 64 patients met sufficient quality criteria to be included. These studies suggest 5-HT and L-tryptophan are better than placebo at alleviating depression (Peto OR = 4.1, 95% CI = 1.3-13.2). However, the small size of the studies, and the large number of inadmissible, poorly executed studies, casts doubt on the result from potential publication bias, and suggests that they are insufficiently evaluated to assess their effectiveness. CONCLUSION: A large body of evidence was subjected to very basic criteria for assessing reliability and validity, and was found to largely be of insufficient quality to inform clinical practice. More well-designed studies are urgently required to enable an assessment of what may be an effective class of agents.

bron


De vraag die je je wel kan stellen is: Zal trytofaan nog goed omgezet worden na een bepaalde periode 5-HTP gebruik?

 

[2Ripped4U]

In me fattburner zit een bepaalde hoeveelheid. Gebruik t niet als supp apart.

 

[Ano_1966]

waarom wil je het gebruiken....? wat is jouw doel hiermee...?

 

[Ano_1966]

waarom wil je het gebruiken....? wat is jouw doel hiermee...?

tja,als je niet reageert kan ik je ook niet helpen,,,,,,,,