Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

[chrisk]

Kwam deze tegen en vond het wel interessant dat leptin ook effect op de testes zou hebben. Wist ik niet. Interessante overview van hormonale invloeden van vetmassa.

Reciprocal interplay between white adipose tissue (WAT) and testis. (a) In normal conditions, circulating androgens control adipocyte size and adipose mass. On the other hand, plasmatic leptin, mainly produced by adipose tissue, regulate testicular steroidogenesis. Dashed bars indicate the reciprocal interplay between testis (through androgens) and adipose tissue (mainly through leptin). (b) Androgen deficiency induces expansion of fat mass and subsequent dysregulation of several functions controlled by adipose tissue such as insulin sensitivity, blood pressure, vascular reactivity, and immunity. The state of insulin resistance determined by obesity leads to reduced production of SHBG. The consequent reduction in testosterone triggers expansion of adipose mass with subsequent increase in aromatase (ARO) activity, which in turn mediates peripheral conversion of testosterone to estradiol. Increased estrogen levels induce a reduction of LH pulse which contributes to the reduction in androgen production. On the other hand, excess of circulating leptin, due to increased adipose mass, disrupts testicular steroidogenesis, with consequent suppression of androgen production. The vicious cycle is triggered.

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic syndrome in men. These observations indicate that there is a strict connection between anatomically and...

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[neet61]

Het is volgens mij wel zo dat dikke jongetjes laat in de puberteit komen (of jongetjes die laat in de puberteit komen vaak dik zijn, ik weet niet waar de causaliteit ligt). Ik zal dit verhaal eens lezen

 

[neet61]

Complex verhaal. Hoog vetpercentage met hoge leptine productie en laag testosteron houden elkaar dus in stand in 'metabool syndroom'.

 

[RonnReeves]

Euhhh, een goeie haan is niet vet ?