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Bigcat

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Bo

Dutch Bodybuilder
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Kwam op een ander forum een echte expert tegen en vroeg hem eens om het artikel "the sane cycle" the bekijken. Misschien interessant voor je om te lezen. Dit was de reactie:

it can actually benefit us in lengthening our life-span and increasing our quality of life.

Certainly this has never been proven in medical literature. Anabolic use can differently increase the quality of life especially older men but increasing life span is purely speculation.

steroids have never led to the death of any person, and that they are far less lethal than most over the counter products, such as plain aspirin, they should really be legal.

I love this argument, comparing AAS to Tylenol, Motrin or Aspirin which can all be hepatotoxic in large consumptions. He makes a valid argument in his analogy, and yes aspirin can cause side-effects (tinnitus, dizziness, heartburn, peptic ulcers, increased bleeding times, etc). What you have to be careful of are the long term side-effects of AAS use. Acutely, I would agree AAS are as safe as any other OTC medication. But medical literature shows that complications can occur later down the road such as heart disease, coronary artery disease, cardiomyopathy.



AAS is not for everyone. I would never advocate the use of AAS for any individual with uncontrolled hypertension (high blood pressure), renal disease (kidney failure), cardiac disease, liver disease or who are on certain medications.


quest to refute the dangers of steroid use have asked me for help in proving these facts to sceptics and laymen, and this is EXTREMELY difficult because of the large amount of propaganda they have had to endure over past years.

100% correct with this statement, media has not helped with AAS use.


For cycle duration I have chosen 12 weeks.

12 weeks is a good happy medium especially for beginners. My cycles are usually between 10-16 weeks. Everyone’s body is different and this one variable which can very greatly from individual to individual.

As a rule we will use equal time off as on.

This is the old golden rule; duration of cycle in weeks = duration off steroids in weeks. This rule is not a commandment of AAS use. Different individuals HPTA will recover at different time intervals. 6 weeks, in my opinion, would be the absolute minimum time off. Certainly if you follow the rule you can be fairly sure that your HPTA will be recovered.



Trenbolone and nandrolone (Deca-Durabolin, Laurabolin, Durabolin) are excluded because they are too suppressive.

He is correct in this statement. Deca and Tren due to their molecular are very androgenic (tren is 3x androgenic than test). As a result, they are very suppressive to the HPTA. I personally like both of these AAS, with the use of HCG one can overcome the HPTA shut-down. My personal opinion is that new AAS users should wait until doing 3-4 cycles before trying tren.


Andriol because it is ineffective

Absolute waist of money- author is dead on with this

oxandrolone (Anavar) because a useful dose (75+ mg per day) is too expensive,

If one can get Anavar at a cheap price it is a wonderful agent for strength and hardness. For those of you who cannot afford it no worries. It’s almost comparable to being on dbol while running Arimidex .25-.50mg (to avoid the bloat) at ¼ the cost.


Primo is a decent androgen, but seems to have no other mode of action.

Never tried primo. There are too many fakes out there and the chances of getting real primo is close to zero. If you look on other boards who have had primo tested, almost all contain little or no active ingredient. Becareful with this one.

We will also exclude methandrostenolone (Dianabol) and oxymetholone (Anadrol). While these are useful drugs at the beginning of a cycle, especially as far as bulk and strength, they fall outside of what we are looking for : a long term cycling plan with relatively lean results.

I somewhat disagree with this statement. Before the availability of anti-es, d-bol would cost tremendous weight gain do to the high aromotization of testosterone to estrogen. This would ultimately cause a lot of bloating. If one were to run Arimidex, femura etc with d-bol the results would be lean muscle without excess bloat. D-bol is a very cost effective drug and when cycled right can cause great increases in strength and mass.

On top of that I want to make a case for stanozolol (Winstrol/Stromba) and I do not feel comfortable recommending the use of two orals, due to liver toxicity (eventhough liver toxicity is a tad exaggerated, but then that just allows us more leeway with the winny).

Winstrol has it’s place for bodybuilders but maybe not for the beginner. Author stands corrected about the liver enzymes being blown out of proportion. What’s more important to realize is the negative impact winstrol has on your HDL. HDL is your good cholesterol (you want this value to be high). If your HDL is low it is actually a risk factor for heart disease. Winny will severly decrease your HDL levels. One should be aware of this so that he/she can get regular lipid screens. To counteract the sides of the HDL, one could take Niacin or lipitor but becareful both of these drugs are hepatotoxic (liver toxic) so your doc will need to watch your LFTs (liver function tests-(ast, alt, GGt)


testosterone. That is why we not only use it, it will be the base for our cycle. And it should be for any health-conscious cycle.

Testosterone should be the base of every cycle that one is one. It is an excellent foundation and when combined with deca/tren can alleviate the coïtusual side-effects. This is a golden rule in cycling “Test is the foundation of every cycle”.


Many people regard DHT as the enemy, because among these androgen-specific tissues are the scalp (aggravating a genetic tendency to hair loss) and the skin (causing outbreaks of acne). But in fact DHT is more than that to us. Since it is the prime androgen in nerve tissue, it will be imperative to have ample DHT levels for optimal neuromuscular response. This is why many people taking the 5-alpha-reductase inhibitor finasteride (Proscar) find that their strength does not increase, or even decreases.

Excellent point on behalf of the author. If trying to prevent hairloss, one should stick to using topical agents to avoid blocking DHT systemically


steroid use has been known to cause or aggravate Benign prostate hypertrophy,

Absolutley correct, we have talked about this topic in recent threads.

But the latest research determines that estrogen is in fact the causative factor, although a level of androgenic action is required. Androgens have actually been proferred as a therapeutic means to treat BPH.

Currently this is still speculation and trials are being conducted. I wish Bigcat would have sited the journal were he got this info. Newer evidence is pointing to the fluctuating levels of androgens in the body. Men who have been castrated still can develop BPH


I have to run and teach a chem class, i'll finish with my thoughts later tonight. Anyone else feel free to critique as well. [/B]
 
these studies go is that TESTOSTERONE, and not steroids in general, is safe and beneficial.

Author is correct in regards to this statement. Here’s what is tricky though. There have been studies done showing testosterone decreases serum lipids( a good thing-decreases chances of cardiac disease) also studies have shown that testosterone can be beneficial to older men. The problem with most of these studies is that they only have a small population size. If anyone has taken statistics one thing you need to check before even reading an article is the population size and the power of the study. You can have a study that shows that shit taste good but if the sample size is small and the power is low the study is worthless and has little merit. Be careful when reading some of these medical studies.


One of the main reasons against the use of steroids has been cardiovascular risk. Several studies have looked at this closely, and not only did they determine that testosterone did not pose a heart risk (6) , they also concluded that low testosterone levels induce cardio-vascular risk (7),

I’m impressed with this statement. Not to many people know about this. Actually just recently (June 2003), a study was done showing that low testosterone increases the risk of athrosclerosis of the aorta (largest blood vessel in the body). Testosterone injection studies done in 2002 showed that they cause vasodilation effects and can improve exercise tolerance in people who have angina (chest pain). Author stands corrected.

whereas supraphysiological administration seemed to decrease the risk (8) (decreases in total cholesterol, HDL and LDL, LDL/HDL ratio and apoplipoprotein B, a marker for cardiovascular risk).

The study he is referring to showed a reduction of about 13% of one’s LDL with testosterone injections. No effect on HDL. Lowering LDL does significantly decrease one’s risk in developing atherosclerosis and heart disease down the road.


In conclusion it is safe to state that testosterone is actually good for your ticker,

This statement is mere speculation. Be careful with these statements. There have been no studies that have been conducted that have proved or refuted the above statement. Just because there is no negative findings with research does not mean it’s good for the heart. Lowering LDL and cholesterol is only one small piece of the puzzle in relation to heart disease. There are many other variables that have to be considered. So don’t hold a lot of weight on this statement.

and as normal levels of testosterone decrease with age, a good case is to be made for Hormonal Replacement therapy in the interest of cardiovascular health.

Cumulative research has shown that testosterone replacement can be very beneficial to older men. Especially those with hypogonadism, osteoporosis, depression, and coïtusual dysfunction. Author stands correct with the above statement.





Well, the propionate is my first choice, because its release patterns seems to be the most beneficial in keeping water weight under control, and it clears faster than the other two allowing for faster recuperation.


The decision of what test to use is just a personal preference issue. I have ambivalent feelings on the statement above. Testosterone is testosterone plain and simple, it doesn’t matter what ester you attach you are still going to get the same side effects with equal dosages. Certainly for beginners using cypionate or enthanate would be a better choice because of less weekly injections.





In defense of boldenone

Boldenone differs from testosterone


Author is just outlining the basic Pathophysiology of Boldenone. Completely agree with EQ profile.


Cycle
Week 1-12 : Testosterone enanthate / cypionate 400-500 mg/week
Or : Testosterone propionate 150 mg every other day

Week 1-2 : Boldenone Undecylenate 600-800 mg/week
Week 3-12 : Boldenone Undecylenate 300-400 mg/week
Week 6-13 : Stanozolol 50-100 mg/day


500mg is perfect for beginners and even intermediate users of AAS. One thing I would suggest is to make sure that the testosterone mg is higher than the EQ. For instance if doing 500mg of test do 400mg of EQ. This would come out to injections just Monday and Thursday (250 of test and 200 mg of EQ for the 12 weeks).



Post cycle

Week 12-14 : HCG 3000/3000/1500/1500 IU / 5days
Week 12-17 : Tamoxifen Citrate 20 mg/day
Week 14-15 : Clomiphene Citrate 100 mg/day
Week 16-17 : Clomiphene Citrate 50 mg/day
Week 14-15 : (Spironolactone) 50 mg/day


Just is just one of the 50 or so post cycle regimens. I personally don’t follow the above. There are so many different combinations, you just have to experiment and find the right one for you.

In my opinion you don’t need HCG for this cycle. The cycle is not long >16 weeks and you are not using and suppressive androgen agents like tren and deca.


~Note: The above are just my opinions from my own personal experience and through countless hours of medical journal research. [/B]


- Kronah
 
Die gast geeft Big Cat in grote lijnen wel gelijk,
maar sommige dingen blijven natuurlijk speculaties.
 
Commentaar is van kronah van rippedmass idd patrick. Hij heeft een medical en masters degree in chemistry en is al jaren gespecialiseerd in as. Was dus wel benieuwd hoe die op dit artikel zou reageren aangezien vrijwel niemand hier de gespecialiseerde kennis heeft om het fijne te weten van bigcats uitspraken.
 
Bo zei:
Certainly this has never been proven in medical literature. Anabolic use can differently increase the quality of life especially older men but increasing life span is purely speculation.

Pure speculatie ? Een verminderd risico op cardiovasculaire aandoeningen, die een van de drie grootste doodsoorzaken is bij mannen boven de 45 is anders wel mooi meegenomen. Als je denkt dat dat in onze westerse samenleving geen grote kans op een langer leven is, dan mag hij vlug terug naar school van mij.

I love this argument, comparing AAS to Tylenol, Motrin or Aspirin which can all be hepatotoxic in large consumptions. He makes a valid argument in his analogy, and yes aspirin can cause side-effects (tinnitus, dizziness, heartburn, peptic ulcers, increased bleeding times, etc). What you have to be careful of are the long term side-effects of AAS use. Acutely, I would agree AAS are as safe as any other OTC medication. But medical literature shows that complications can occur later down the road such as heart disease, coronary artery disease, cardiomyopathy.


Dit zet ik in het Engels, mag je hem gerust eens voorleggen ...

Likewise I love this particular argument. Especially since testosterone has been shown in a multitude of recent studies to prevent most of these conditions and improve cardiovascular condition, maintaining or lowering cholesterol, lowering LDL, maintaining HDL, increasing HDL/LDL ratio, lowering Lp(a), a marker for cardiovascular risk, and preventing many of the negative effects of IGF-1 in vascular endothelial tissue. The only possibly negative comment I have read in this regard, was a study that suggested that testosterone MAY attenuate exercise-induced vascularization of the heart. Of course this argument only holds true for testosterone use without concomittant use of all kinds of pussy aromatase blockers. This is one of the reasons I employ test as a base for any stack and suggest only testosterone to any recreative user.

AAS is not for everyone. I would never advocate the use of AAS for any individual with uncontrolled hypertension (high blood pressure), renal disease (kidney failure), cardiac disease, liver disease or who are on certain medications.


Safe for hypertension, I'm quite positive that science will prove you wrong not too far down the road. But be it known that I don't recommend steroid use to people who do not need it. Period.

100% correct with this statement, media has not helped with AAS use.


And keeps testosterone from being used and tested in many more settings where it could have numerous benefits.

12 weeks is a good happy medium especially for beginners. My cycles are usually between 10-16 weeks. Everyone’s body is different and this one variable which can very greatly from individual to individual.

Its the only decent length for which I could in some degree verify complete recovery in 5-6 weeks. Varying strongly individually of course. But some assurance is better than none.

This is the old golden rule; duration of cycle in weeks = duration off steroids in weeks. This rule is not a commandment of AAS use. Different individuals HPTA will recover at different time intervals. 6 weeks, in my opinion, would be the absolute minimum time off. Certainly if you follow the rule you can be fairly sure that your HPTA will be recovered.

I did say rule and not commandment. For all those stubborn people out there who do not take my advise and insist on using steroids without medical supervision, I find this guideline to be invaluable. Of course its not written in stone. And of course its always better to make sure with blood tests, as I do always recommend. But providing this guideline is better than having them take a stab at it ...

He is correct in this statement. Deca and Tren due to their molecular are very androgenic (tren is 3x androgenic than test). As a result, they are very suppressive to the HPTA. I personally like both of these AAS, with the use of HCG one can overcome the HPTA shut-down. My personal opinion is that new AAS users should wait until doing 3-4 cycles before trying tren.

I've seen good results in athletes using it as a first cycle drug as well. The dangers of tren are highly exaggerated, and if one can manufacture the injects in a sterile environment from a verified pure powder source I tend to find that most find it no more harsh than other drugs. I'm also partial to trenbolone for a multitude of reasons, its increased androgenicity, lack of binding to proteins, good stability at the receptors, its downregulation of glucocorticoid receptors and so on. Nandrolone on the other hand I find the most disgusting thing out there and the downsides by far outweigh the positives, keeping in mind that I don't give a rats ass about aesthetics. If you don't want to lose your hair, don't do steroids, simple as that.

If one can get Anavar at a cheap price it is a wonderful agent for strength and hardness. For those of you who cannot afford it no worries. It’s almost comparable to being on dbol while running Arimidex .25-.50mg (to avoid the bloat) at ¼ the cost.


Quite true, both are a total waste of money comparing gains to price. In any category and in any field. Better alternatives are at hand, easier and cheaper.


Never tried primo. There are too many fakes out there and the chances of getting real primo is close to zero. If you look on other boards who have had primo tested, almost all contain little or no active ingredient. Becareful with this one.

The benefits of lab testing. Of course not everyone has this at their disposal. In any case your words substantiate that primo is not a good choice, albeit for another reason.

I somewhat disagree with this statement. Before the availability of anti-es, d-bol would cost tremendous weight gain do to the high aromotization of testosterone to estrogen.


While on dbol, testosterone is severely supressed, so how can aromatization of testosterone to estrogen be a problem ? The reason for the bloat is the fact that besides being a more powerful estrogen than estradiol, 17-alpha-methyl estradiol is also a more potent upregulator of aldosterone. And it is the increased aldosterone that causes the bloat.

This would ultimately cause a lot of bloating. If one were to run Arimidex, femura etc with d-bol the results would be lean muscle without excess bloat. D-bol is a very cost effective drug and when cycled right can cause great increases in strength and mass.


Dbol is highly dependent on its estrogenic component for gains. When reducing the aromatisation, as we can see with analogues like esiclene, gains are next to nothing. Same observations can be made with boldenone. While studies have shown the androgenic component to be necessary for the muscle growth caused by dbol, extensive evidence has also pointed out that the androgenic activity of dbol is too small to be significant on its own. Like you said, no more effective than low dose anavar.

Winstrol has it’s place for bodybuilders but maybe not for the beginner. Author stands corrected about the liver enzymes being blown out of proportion. What’s more important to realize is the negative impact winstrol has on your HDL. HDL is your good cholesterol (you want this value to be high). If your HDL is low it is actually a risk factor for heart disease. Winny will severly decrease your HDL levels. One should be aware of this so that he/she can get regular lipid screens. To counteract the sides of the HDL, one could take Niacin or lipitor but becareful both of these drugs are hepatotoxic (liver toxic) so your doc will need to watch your LFTs (liver function tests-(ast, alt, GGt)


Or one could take a heavily aromatizing steroid like testosterone, as is the case here, or even a SERM to counteract negative effects on lipid profiles. I would also object to terming any type of drug as suited for a beginner or not. Unlike you I do insist that people under my guidance using steroids must see a physician on a regular basis, every three weeks. In such a setting none of the complications named could pose any threat to the safe and effective use of any substance. Although, as said earlier, I wouldn't give anything but test to a recreational user.

Winstrol has many potential uses for the athlete. Besides a totally different AR activation profile to any other steroid known to man, the existence of specific binding proteins for it in the liver and the fact that it may antagonize GABAergic effects of testosterone in the brain, it also shows many of the non-genomic characteristics of progesterone, without nominal genomic activation of the PR. With which I allude to its ability to bind and block low affinity glucocorticoid receptors and increase calcium retention (which could level blood calcium after testosterone increases calcium influx).

Currently this is still speculation and trials are being conducted. I wish Bigcat would have sited the journal were he got this info. Newer evidence is pointing to the fluctuating levels of androgens in the body. Men who have been castrated still can develop BPH

True enough, I may have oversimplified this point, the specifics of BPH are still a little hazy. But the succesful treatment of BPH with DHT does make this point more than likely, at least from a practical viewpoint.
 
Bo zei:
Author is correct in regards to this statement. Here’s what is tricky though. There have been studies done showing testosterone decreases serum lipids( a good thing-decreases chances of cardiac disease) also studies have shown that testosterone can be beneficial to older men. The problem with most of these studies is that they only have a small population size. If anyone has taken statistics one thing you need to check before even reading an article is the population size and the power of the study. You can have a study that shows that shit taste good but if the sample size is small and the power is low the study is worthless and has little merit. Be careful when reading some of these medical studies.


Indeed. But I'm not pulling the figures out of my ass here. These findings are consistent with EVERY single bloodtest I have administered so far. That's some 34 athletes and 150+ cycles. Coincidentally this also proved the fact that reducing estrogen did decrease positive cardiac influence, and that the benificial effects are not linearly dose-responsive. But neither of these is admissable evidence since it comes from data that is unverifiable to the reader. Hence the studies.

I’m impressed with this statement. Not to many people know about this. Actually just recently (June 2003), a study was done showing that low testosterone increases the risk of athrosclerosis of the aorta (largest blood vessel in the body). Testosterone injection studies done in 2002 showed that they cause vasodilation effects and can improve exercise tolerance in people who have angina (chest pain). Author stands corrected.

Could references be provided for this ? Most evidence shows that the aromatization of testosterone reduces atherosclerotic risk. As well as other numerous negative effects on the cardiovascular system. Likewise I am equally impressed that you know of this. Times that I meet people with such enlightenment are few and far between.

This statement is mere speculation. Be careful with these statements. There have been no studies that have been conducted that have proved or refuted the above statement. Just because there is no negative findings with research does not mean it’s good for the heart. Lowering LDL and cholesterol is only one small piece of the puzzle in relation to heart disease. There are many other variables that have to be considered. So don’t hold a lot of weight on this statement.

I didn't say it was a cure for heart disease, i said using testosterone decreases the risk thereof. Of course there are multiple factors to consider, in physiology there always are, but that doesn't change the fact that every one of these studies demonstrates positive effects on the heart.

The decision of what test to use is just a personal preference issue. I have ambivalent feelings on the statement above. Testosterone is testosterone plain and simple, it doesn’t matter what ester you attach you are still going to get the same side effects with equal dosages. Certainly for beginners using cypionate or enthanate would be a better choice because of less weekly injections.

Nope, I'm sorry. You are not correct on this one. Believe me, I held the same belief for too long a time and have had to alter my opinion. Try administering a suspension and compare to prop. The bloat and risk of gyno is excessively greater with the susp, at an equal dose of base susbstance (ester weight of prop not counted). The reason for this is of course not that the pharmacology of testosterone changes, the ester is detached when it reaches the blood. But the release rate is different. A massive increase in serum testosterone as seen with susp causes larger occupation of 5AR and aromatase, resulting in high DHT, estradiol, androstenedione and SHBG. All of these effects explain the powerful but less than aesthetic effects of susp compared to prop, whose solid release rate allows for timed release and less drastic occupation of 5AR and aromatase. A recent study, and this astrounded even me, also pointed out that the longer the ester the bigger the gains. I haven't read it in its entirety, so i won't support or deny this statement, but its definitely a new look at things.

500mg is perfect for beginners and even intermediate users of AAS. One thing I would suggest is to make sure that the testosterone mg is higher than the EQ. For instance if doing 500mg of test do 400mg of EQ. This would come out to injections just Monday and Thursday (250 of test and 200 mg of EQ for the 12 weeks).


Agree entirely, goes for all steroids. Test should be the base. Here the first two weeks do not adhere to this principle, simply because of the bold front-load.

Just is just one of the 50 or so post cycle regimens. I personally don’t follow the above. There are so many different combinations, you just have to experiment and find the right one for you.


From your above comments I did not expect this statement from you. While much is left to be discussed about the best possible post-cycle, its still a largely physiological fact and last I checked Physiology and biochemistry and endocrinology were still exact sciences. That means if inter-individual changes are noted, we haven't dug deep enough to find all the causes of supression. When we have all the facts however, a single uniform best treatment can be made.

In my opinion you don’t need HCG for this cycle. The cycle is not long >16 weeks and you are not using and suppressive androgen agents like tren and deca.


Nut shrinkage can set in after only 4 weeks. Optimal testicle size and responsiveness to LH will increase chances of a speedier recovery. In any cycle exceeding 6 weeks. Although in my opinion anything under 10 is a waste.

~Note: The above are just my opinions from my own personal experience and through countless hours of medical journal research.

Likewise, and I much appreciate your honest critiscism.
 
ik zal je antwoord eens posten :-)
 
now who's the specialist huh !? :D
 
Alle twee, voor het overgrote deel weet hij duidelijk waarover hij praat.
 
~Hey thanks dom!inator, Big Cat seems like a pretty knowledgable fellow. Glad to see that he respects my thoughts and that we see eye to eye on a lot of things. Feel free to post his replies if you would like on rippedmass for people to read. Not sure if the other guys on site that replied to what i said were good or not. Wish i could read the language, hopefully they were nice to me. Take care bro.
 
Jay Impel zei:


Nandi12 is de Admin van CuttingEdgeMuscle, en moderator op een hele hoop amerikaanse boards. Is hoogleraar, en 1 van de meest geleerde BB-er die er rondlopen.
En blijkbaar is ToxiQ een fan van m :)

Een van de weinigen waar Bigcat wel mee door 1 deur kan :D.
 
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