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Co-ingestion of protein and leucine stimulates muscle protein synthesis rates .....

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3XL

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Am J Clin Nutr. 2006 Sep;84(3):623-32. Links
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.
* Koopman R,
* Verdijk L,
* Manders RJ,
* Gijsen AP,
* Gorselink M,
* Pijpers E,
* Wagenmakers AJ,
* van Loon LJ.

Departments of Human Biology and Movement Sciences, Maastricht University, Maastricht, Netherlands; Numico Research BV, Wageningen, Netherlands.

BACKGROUND: The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover.

OBJECTIVE: We investigated the effects on whole-body protein balance and mixed-muscle protein synthesis rates of the ingestion of carbohydrate with or without protein and free leucine after simulated activities of daily living.

DESIGN: Eight elderly (75 +/- 1 y) and 8 young (20 +/- 1 y) lean men were randomly assigned to 2 crossover experiments in which they consumed either carbohydrate (CHO) or carbohydrate plus protein and free leucine (CHO+Pro+Leu) after performing 30 min of standardized activities of daily living. Primed, continuous infusions with l-[ring-(13)C(6)]phenylalanine and l-[ring-(2)H(2)]tyrosine were applied, and blood and muscle samples were collected to assess whole-body protein turnover and the protein fractional synthetic rate in the vastus lateralis muscle over a 6-h period. RESULTS: Whole-body phenylalanine and tyrosine flux were significantly higher in the young than in the elderly men (P < 0.01). Protein balance was negative in the CHO experiment but positive in the CHO+Pro+Leu experiment in both groups. Mixed-muscle protein synthesis rates were significantly greater in the CHO+Pro+Leu than in the CHO experiment in both the young (0.082 +/- 0.005%/h and 0.060 +/- 0.005%/h, respectively; P < 0.01) and the elderly (0.072 +/- 0.006%/h and 0.043 +/- 0.003%/h, respectively; P < 0.01) subjects, with no significant differences between groups.

CONCLUSIONS: Co-ingestion of protein and leucine with carbohydrate after activities of daily living improves whole-body protein balance, and the increase in muscle protein synthesis rates is not significantly different between lean young and elderly men.

http://www.ajcn.org/cgi/reprint/84/3/623.pdf
 

builderB

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Bedankt voor de link 3XL.

Handig voor school dit! :D
 

Svensson

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Heb vorig jaar college gehad van Luc van Loon.. toen had hij het geloof ik al over de bijzonder anabole eigenschappen van leucine.
Erg interessant, zeker iets om in de gaten te houden!
 

Miss Deadlift

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Dus ze hebben aan 1 groep alleen koolhydraten gegeven,en aan de andere groep koolhydraten+proteine+ leucine.
Waarom hebben ze niemand koolhydraten+proteine gegeven? Nu is het imo nog niet echt duidelijk of die leucine nu toegevoegde waarde heeft...Dat proteine toegevoegde waarde heeft wisten we iig al lang :rolleyes:
 

hypnotizedman

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@xxl: nogmaals bedankt. Weer een bijzonder boeiende post. Had het ook al aangegeven dat leucine werkt. De ideale dosering zou 0.2gram per kilogram zijn. Het feit dat ik weet dat het werkt en de optimale dosering werd eveneens aangegeven door een prof van de universiteit Leuven. Vrij geroemd in dit soort onderzoeken; ben zijn naam echter vergeten...
 

3XL

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De Maeyer ?
 

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