Originally posted by Diver2000
Sorry hoor maar een hoop vrouwen die ik ken hebben op een leeftijd van rond de 20 ook een iets dikker buikje dan de meeste mannen. Ook bij vrouwen is dat de plek waar het erg slecht weggaat. Lijkt mij dan ook niet van de test te komen.
Oestrogeen heeft een goede binding voor vet op heupen benen buik en schouders.
Nee oestrogeen heeft juist weinig binding op de buik. De meeste vrouwen slaan het grootste deel van de vet op bij de benen. Daar gaat het vaak ook het laatst weg. Dat sommige vrouwen meer vet bij de buik opslaan kan wel te maken hebben met testosteron. Daarnaast komt er natuurlijk altijd wel vet op de buik naarmate het vetpercentage hoger wordt. En er zijn ook weer altijd uitzonderingen. Hier wat abstracts:
The free testosterone to dehydroepiandrosterone sulphate molar ratio as a marker of visceral fat accumulation in premenopausal obese women.
De Pergola G, Triggiani V, Giorgino F, Cospite MR, Garruti G, Cignarelli M, Guastamacchia E, Giorgino R.
Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche, Universita degli Studi di Bari, Italy.
The aim of this paper was to investigate the relationship between coïtus hormones and fat distribution in premenopausal obese women. Serum concentrations of coïtus hormones, glucose tolerance and fat distribution were determined in a population of non-diabetic obese women, in the outpatient clinic of University Hospital, Bari, Italy. The subjects were 40 consecutive premenopausal obese women (BMI > 25). The amounts of visceral, abdominal subcutaneous, and femoral subcutaneous fat, and the visceral to abdominal subcutaneous fat ratio were measured by ultrasound techniques. Serum concentrations of total testosterone (T), free testosterone (FT), dehydroepiandrosterone sulphate (DHEAS), delta 4-androstenedione (A), 17-beta-estradiol (E2), coïtus hormone binding globulin (SHBG), and the FT to DHEAS molar ratio were measured during the follicular phase. Plasma glucose and insulin concentrations were evaluated during an oral glucose tolerance test. Of all coïtus hormones, the FT/DHEAS molar ratio was the parameter that most closely related to the amount of visceral fat (r: 0.544, P < 0.001), and this positive association was maintained (P < 0.01) after adjustment for age, BMI and insulin levels (fitted model: R2 adjusted: 0.504; F ratio: 14.73; P-value: < 0.0001). DHEAS was inversely correlated with the amount of visceral fat (r: -0.324, P < 0.05). T was correlated with the amounts of both abdominal subcutaneous (r: -0.409, P < 0.01) and visceral fat (r: -0.324, P < 0.05). The FT to DHEAS molar ratio is the androgenic parameter that most closely relates to the accumulation of visceral fat in premenopausal obese women.
In conclusion, in obese premenopausal women, visceral fat predominance seems to be related to a relatively increased androgenicity
Obesity and metabolic complications: contribution of dehydroepiandrosterone and other steroid hormones.
Tchernof A, Labrie F, Belanger A, Despres JP.
Liptd Research Center, Clinical Research Center, Sle foy, Quebec, Canada.
Obesity is a heterogeneous condition and not every obese patient is at increased risk of cardiovascular diseases (CVD). It is now well established that the regional distribution of body fat is a critical correlate of the metabolic complications of obesity. Studies that have assessed adipose tissue distribution by imaging techniques such as computed tomography have demonstrated the importance of the intra-abdominal (visceral) fat depot as a marker of a cluster of metabolic abnormalities which include glucose intolerance, insulin resistance, hyper-insulinemia, hypertriglyceridemia, elevated number of apo B-carrying lipoproteins as well as hypoalphalipoproteinemia. Although the association between visceral obesity and metabolic complications can hardly be questioned, it has been suggested that it may not necessarily represent a causal relationship. For instance, concomitant alterations in coïtus steroid levels have been found in both men and women with abdominal (visceral) obesity which have also been reported to be significantly correlated with the insulin resistant-dyslipidemic state found in abdominal obese subjects. In women, abdominal obesity is associated with increased free testosterone concentrations and reduced coïtus hormone binding globulin (SHBG) levels, whereas in men this condition is associated with reduced testosterone and adrenal C12 steroid (dehydroepiandrosterone, androstenedione, androstene-3 beta, 17 beta-diol) levels as well as decreased SHBG concentrations. These altered steroid and SHBG; levels have been reported to be independent correlates of the metabolic complications of visceral obesity although they cannot solely account for the increased CVD risk found in these patients. In this regard, intervention studies are clearly warranted to better quantity the respective contribution of excess visceral adipose tissue and of the concomitant alterations in coïtus steroid levels as modulators of metabolic disturbances increasing CVD risk in obesity.
In women, abdominal obesity is associated with increased free testosterone concentrations and reduced coïtus hormone binding globulin (SHBG) levels In conclusion, in obese premenopausal women, visceral fat predominance seems to be related to a relatively increased androgenicity