Effect op spieren, kracht en proteïne metabolisme.
Effect of growth hormone and resistance exercise on muscle growth in young men
http://ajpendo.physiology.org/content/262/3/E261.short
Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.
http://jcem.endojournals.org/content/79/5/1361.short
The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men
http://jp.physoc.org/content/555/1/231.abstract
Short-term growth hormone treatment does not increase muscle protein synthesis in experienced weight lifters
http://jap.physiology.org/content/74/6/3073.short
Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men.
http://jcem.endojournals.org/content/81/1/421.short
Growthhormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans
http://www.sciencedirect.com/science/article/pii/002604959390285V
Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man
[Link niet meer beschikbaar]
Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans
http://ajpendo.physiology.org/content/260/3/E499.short
Myostatin Is a Skeletal Muscle Target of Growth Hormone Anabolic Action
http://jcem.endojournals.org/content/88/11/5490.short
Growth hormone and athletes.
http://ukpmc.ac.uk/abstract/MED/3299611
Growth hormone administration to normal animals leads to muscle hypertrophy, but this muscular growth is not accompanied by increased strength.
---------- Post toegevoegd Tue 10 Jul 2012 om 18:48 ----------
Bijwerkingen en uitleg.
http://en.wikipedia.org/wiki/Cytochrome_P450
http://en.wikipedia.org/wiki/CYP3A4
Cytochrome P450 Inhibition: Frequently Asked Questions
[Link niet meer beschikbaar]
P450 Drug Interaction Table: Abbreviated "Clinically Relevant" Table
http://medicine.iupui.edu/clinpharm/ddis/clinical-table/
Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver
http://www.researchgate.net/publica...e_P450_mRNAs_by_growth_hormone_in_mouse_liver
Growth hormone regulation of hepatic cytochrome P450 expression in the rat
http://www.ncbi.nlm.nih.gov/pubmed/1496921
Growth Hormone Regulation of Sex-Dependent Liver Gene Expression
http://mend.endojournals.org/content/20/11/2613.short
Gender differences in drug metabolism regulated by growthhormone
http://www.sciencedirect.com/science/article/pii/1357272594000565
Sexually Dimorphic Regulation of Hepatic Isoforms of Human Cytochrome P450 by Growth Hormone
http://jpet.aspetjournals.org/content/316/1/87.full.pdf
Sex-specific, Growth Hormone-regulated Transcription of the cytochrome P450 2C11 and 2C12 genes.
[Link niet meer beschikbaar]
Somatostatin is required for masculinization of growth hormone–regulated hepatic gene expression but not of somatic growth
http://www.jci.org/articles/view/11941
A dual role of growth hormone as a feminizing and masculinizing factor in the control of coïtus-specific cytochrome P-450 isozymes in rat liver
http://joe.endocrinology-journals.org/content/120/2/311.abstract
enz... http://scholar.google.be/scholar?sta...sdt=0&as_vis=1
The Effect of Ageing on Cytochrome P450 Enzymes: Consequences for Drug Biotransformation in the Elderly
http://www.google.nl/url?sa=t&rct=j...SGPgPpgQfwkVZgqA9F0kzdQ&bvm=bv.53217764,d.ZGU
'Anti-aging' Growth Hormone May Shorten (Not Lengthen) Life
[Link niet meer beschikbaar]
Growth Hormone May Shorten Life Span, Study Finds
http://www.ohio.edu/news/00-01/98.html
http://en.wikipedia.org/wiki/Telomere
Telomeres and Aging - Understanding Cellular Aging
http://longevity.about.com/od/researchandmedicine/p/telomeres.htm
Tamoxifen Alters Hepatic Cytochrome P450 Enzyme Expression and Circulating Growth Hormone Levels in Intact Male Rats
http://www.pharmagateway.net/ArticlePage.aspx?DOI=10.1023/B:PHAM.0000041458.81836.c4
Binding prolactine receptor.
http://www.drugbank.ca/drugs/DB00052
Prolactin receptor
Pharmacological action: yes
This is a receptor for the anterior pituitary hormone prolactin
Organism class: human
UniProt ID: P16471
Gene: PRLR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
1.Keeler C, Jablonski EM, Albert YB, Taylor BD, Myszka DG, Clevenger CV, Hodsdon ME: The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range. Biochemistry. 2007 Mar 6;46(9):2398-410. Epub 2007 Feb 6. Pubmed
2.Ahmed TA, Buzzelli MD, Lang CH, Capen JB, Shumate ML, Navaratnarajah M, Nagarajan M, Cooney RN: Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1793-803. Epub 2007 Mar 29. Pubmed
3.Moderscheim TA, Gorba T, Pathipati P, Kokay IC, Grattan DR, Williams CE, Scheepens A: Prolactin is involved in glial responses following a focal injury to the juvenile rat brain. Neuroscience. 2007 Mar 30;145(3):963-73. Epub 2007 Feb 20. Pubmed
4.Cunningham BC, Bass S, Fuh G, Wells JA: Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science. 1990 Dec 21;250(4988):1709-12. Pubmed
Effect of growth hormone and resistance exercise on muscle growth in young men
http://ajpendo.physiology.org/content/262/3/E261.short
Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.
http://jcem.endojournals.org/content/79/5/1361.short
The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men
http://jp.physoc.org/content/555/1/231.abstract
Short-term growth hormone treatment does not increase muscle protein synthesis in experienced weight lifters
http://jap.physiology.org/content/74/6/3073.short
Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men.
http://jcem.endojournals.org/content/81/1/421.short
Growthhormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans
http://www.sciencedirect.com/science/article/pii/002604959390285V
Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man
[Link niet meer beschikbaar]
Growth hormone acutely stimulates forearm muscle protein synthesis in normal humans
http://ajpendo.physiology.org/content/260/3/E499.short
Myostatin Is a Skeletal Muscle Target of Growth Hormone Anabolic Action
http://jcem.endojournals.org/content/88/11/5490.short
Growth hormone and athletes.
http://ukpmc.ac.uk/abstract/MED/3299611
Growth hormone administration to normal animals leads to muscle hypertrophy, but this muscular growth is not accompanied by increased strength.
---------- Post toegevoegd Tue 10 Jul 2012 om 18:48 ----------
Bijwerkingen en uitleg.
http://en.wikipedia.org/wiki/Cytochrome_P450
http://en.wikipedia.org/wiki/CYP3A4
Cytochrome P450 Inhibition: Frequently Asked Questions
[Link niet meer beschikbaar]
P450 Drug Interaction Table: Abbreviated "Clinically Relevant" Table
http://medicine.iupui.edu/clinpharm/ddis/clinical-table/
Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver
http://www.researchgate.net/publica...e_P450_mRNAs_by_growth_hormone_in_mouse_liver
Growth hormone regulation of hepatic cytochrome P450 expression in the rat
http://www.ncbi.nlm.nih.gov/pubmed/1496921
Growth Hormone Regulation of Sex-Dependent Liver Gene Expression
http://mend.endojournals.org/content/20/11/2613.short
Gender differences in drug metabolism regulated by growthhormone
http://www.sciencedirect.com/science/article/pii/1357272594000565
Sexually Dimorphic Regulation of Hepatic Isoforms of Human Cytochrome P450 by Growth Hormone
http://jpet.aspetjournals.org/content/316/1/87.full.pdf
Sex-specific, Growth Hormone-regulated Transcription of the cytochrome P450 2C11 and 2C12 genes.
[Link niet meer beschikbaar]
Somatostatin is required for masculinization of growth hormone–regulated hepatic gene expression but not of somatic growth
http://www.jci.org/articles/view/11941
A dual role of growth hormone as a feminizing and masculinizing factor in the control of coïtus-specific cytochrome P-450 isozymes in rat liver
http://joe.endocrinology-journals.org/content/120/2/311.abstract
enz... http://scholar.google.be/scholar?sta...sdt=0&as_vis=1
The Effect of Ageing on Cytochrome P450 Enzymes: Consequences for Drug Biotransformation in the Elderly
http://www.google.nl/url?sa=t&rct=j...SGPgPpgQfwkVZgqA9F0kzdQ&bvm=bv.53217764,d.ZGU
'Anti-aging' Growth Hormone May Shorten (Not Lengthen) Life
[Link niet meer beschikbaar]
Growth Hormone May Shorten Life Span, Study Finds
http://www.ohio.edu/news/00-01/98.html
http://en.wikipedia.org/wiki/Telomere
Telomeres and Aging - Understanding Cellular Aging
http://longevity.about.com/od/researchandmedicine/p/telomeres.htm
Tamoxifen Alters Hepatic Cytochrome P450 Enzyme Expression and Circulating Growth Hormone Levels in Intact Male Rats
http://www.pharmagateway.net/ArticlePage.aspx?DOI=10.1023/B:PHAM.0000041458.81836.c4
Binding prolactine receptor.
http://www.drugbank.ca/drugs/DB00052
Prolactin receptor
Pharmacological action: yes
This is a receptor for the anterior pituitary hormone prolactin
Organism class: human
UniProt ID: P16471
Gene: PRLR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
1.Keeler C, Jablonski EM, Albert YB, Taylor BD, Myszka DG, Clevenger CV, Hodsdon ME: The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range. Biochemistry. 2007 Mar 6;46(9):2398-410. Epub 2007 Feb 6. Pubmed
2.Ahmed TA, Buzzelli MD, Lang CH, Capen JB, Shumate ML, Navaratnarajah M, Nagarajan M, Cooney RN: Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1793-803. Epub 2007 Mar 29. Pubmed
3.Moderscheim TA, Gorba T, Pathipati P, Kokay IC, Grattan DR, Williams CE, Scheepens A: Prolactin is involved in glial responses following a focal injury to the juvenile rat brain. Neuroscience. 2007 Mar 30;145(3):963-73. Epub 2007 Feb 20. Pubmed
4.Cunningham BC, Bass S, Fuh G, Wells JA: Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science. 1990 Dec 21;250(4988):1709-12. Pubmed