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Spironolactone (Aldactone)
- Topic starter BBwannabe
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- Topic Starter
- #3
Lately a lot of research has been done on using spironolactone as an anti-androgen. Since most competitors will use a diuretic for no more than 5-10 days, this needn't really concern us. It has also raised a lot of questions about whether or not spironolactone can therefore have a use for us in preventing hair loss, acne1 and prostate hypertrophy2, the most frequent of androgenic side-effects. So I would like to answer these questions here. The studies do indeed show that spironolactone can remedy some androgen-mediated conditions, and does so through other means than finasteride (proscar). Finasteride blocks the 5-alpha-reductase enzyme, which converts dehydro steroids to their more androgenic dihydro forms. Like converting testosterone to DHT. But the majority of steroids used, especially when cutting, are already dihydro forms and finasteride has no use, since the 5-alpha reductase enzyme no longer has effect on the androgenic potency. But spironolactone has been shown to work through other pathways3. Its steran nucleus would suggest that it binds the androgen receptor itself, but is not potent enough to, or structurally incapable of (I would opt for the latter) activating it. Its effect on androgens would comparable to the effect that clomid or Nolvadex would have on estrogens.
So what's the final verdict? It may have some use in reducing androgenic side-effects, but only because it blocks the androgen receptor. That means for every bit of side-effects you block, you will lose an equal amount of gains. That also mean to completely eliminate side-effects, you would completely eliminate gains, and might as well not take steroids at all, instead of wasting money on two products that cancel each other out. In short there is no way of preventing side-effects completely, and those people who fear side-effects more than they want gains, should still stay away from steroids altogether. Either you want the gains bad enough, or you don't. If you don't then don't touch the stuff. If you do, then you come to terms with the risk of side-effects.
That doesn't mean the anti-androgenic properties of spironolactone are completely useless to use. Using them post-cycle can be very effective. The aim is to get testosterone back online as soon as possible, and that means eliminating negative feedback. From estrogen first of all, through the help of clomid or Nolvadex, but also by eliminating negative feedback from androgens, and here spironolactone can help. Running it alongside HCG and then to the end of Nolvadex/Clomid treatment. The result is less side-effects from the HCG (acne, water retention), a synergistic effect with the Clomid/Nolvadex to reduce water retention and it stops the continuation of side-effects. Many times users of androgenic steroids will notice that hair loss continues or even starts after a cycle is done, especially with long acting injectable esters. That's too much, we don't have to tolerate more side-effects than what we need for optimal gains after all. And the spironolactone can prevent androgenic side
So what's the final verdict? It may have some use in reducing androgenic side-effects, but only because it blocks the androgen receptor. That means for every bit of side-effects you block, you will lose an equal amount of gains. That also mean to completely eliminate side-effects, you would completely eliminate gains, and might as well not take steroids at all, instead of wasting money on two products that cancel each other out. In short there is no way of preventing side-effects completely, and those people who fear side-effects more than they want gains, should still stay away from steroids altogether. Either you want the gains bad enough, or you don't. If you don't then don't touch the stuff. If you do, then you come to terms with the risk of side-effects.
That doesn't mean the anti-androgenic properties of spironolactone are completely useless to use. Using them post-cycle can be very effective. The aim is to get testosterone back online as soon as possible, and that means eliminating negative feedback. From estrogen first of all, through the help of clomid or Nolvadex, but also by eliminating negative feedback from androgens, and here spironolactone can help. Running it alongside HCG and then to the end of Nolvadex/Clomid treatment. The result is less side-effects from the HCG (acne, water retention), a synergistic effect with the Clomid/Nolvadex to reduce water retention and it stops the continuation of side-effects. Many times users of androgenic steroids will notice that hair loss continues or even starts after a cycle is done, especially with long acting injectable esters. That's too much, we don't have to tolerate more side-effects than what we need for optimal gains after all. And the spironolactone can prevent androgenic side
- Lid geworden
- 2 apr 2003
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- 5.432
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na de kuur neej als je met androgene middelen stopt zoals provi of winny of wat dan ook word het weer minder. moet mij op moment minimaal elke dag scheren terwijl normaal 2 a 3 x in de week genoeg is. als je stopt begint het weer langzamer. alleen dat ****ing borsthaar bevalt me niet echt.
- Lid geworden
- 2 apr 2003
- Berichten
- 5.432
- Waardering
- 134
kaalheid op je 21 ste. kweet niet precies wat in je kuur zit. maar kijk de volgende x uit met anabolen die erg androgeen zijn.
