The effect of increasing concentrations of testosterone (T) and 19-nortestosterone (N) on the in vitro metabolism of [3H]N in minced tissue of the rat seminal vesicle indicates that T and N are equally appropriate substrates for the 5 alpha-reductase. Experiments in which increasing concentrations of 17-methyl-T (MT) or 1-ene-MT were incubated with [3H]T and vesicular mince have revealed that the formation of [3H]5 alpha-dihydro-T is suppressed markedly by MT while 1-ene-MT has no measurable effect. Since 5 alpha-dihydro-MT binds to the androgen receptor with a higher affinity than MT does and (relative to T) MT does not exhibit myotropic-androgenic (= M-A) dissociation, it can be concluded that MT is, whereas 1-ene-MT is not a substrate for the 5 alpha-reductase. Our present and previous data suggest that N exemplifies one class of anabolic steroids that become less androgenic due to 5 alpha-reduction, it shows high myotropic activity, M-A dissociation (= 7-30) and affinity to the androgen receptor. On the other hand, 1-ene-MT belongs to another class of anabolic steroids that are not substrates for the 5 alpha-reductase, exhibit a relatively small myotropic activity, M-A dissociation (= 2-3) and receptor affinity.
[Bron National Libary of Medicine]
[Abeelding niet meer beschikbaar] Jimbo zegt:
Haaruitval hangt af van de mate waarin het anabool hecht aan de androgeenreceptoren en de concentratie receptoren in je haarzakjes.
Deca hecht sterker aan je androgeenreceptoren dan testosteron. Maar deca zet niet om in DHT waardoor de nettobelasting iets minder is dan die van Testosteron. Maar dan maak je alsnog kans op haaruitval als je er gevoellig voor bent.