If the working matters cristalize in the injectiondepot that hurts and mostly if you want to put over 300 mg/ml of Testosterone esters in a ml of "oil" you'd have to crank up the benzyl alcohol level to around 25%. Of course, that’ll hurt quite a bit and might cause localized cellulitis and possibly necrosis and erosion of tissue. And an injection will hurt quite a bit for a few days. In this T-500 testosteron esterifications have been used that can't cristalize between each other. In fact it can be increased to 600 mg/ml without causing pain after injection . A bigger content of the carrier is a co-solvent that is not alcoholbased. HCL wants to bring out highly dosed compounds because of this study.
Volume and Concentration
Steroids come in all shapes and sizes. In other words, you can find nandrolone (or Testosterone or boldenone) esters in 25 mg/ml, 50 mg/ml, 100 mg/ml, 200 mg/ml and so forth. Is a 400 mg injection using two milliliters of a 200 mg/ml oily solution the same as using four milliliters of a 100 mg/ml solution? After all, the net amount is still 400 mg, right? Unfortunately, this isn’t the case.
Steroid concentration in the solution greatly affects the dynamics and kinetics. In this study, some of the men received a 100 mg/ml injection of nandrolone decanoate and other men received a 100 mg injection using a 25 mg/ml solution (which means they received four milliliters, of course). Those that received the 100 mg/ml injection reached significantly higher (between 30% and 50%) plasma levels of nandrolone than those who got 100 mg via the 25 mg/ml solution. To top it off, the 100 mg/ml group’s plasma nandrolone level stayed elevated for a little bit longer; however, the length of suppression of endogenous Testosterone was almost identical.
What does this tell us? It tells us that if we want to maximize plasma levels of hormone (and thereby, maximize gains in lean muscle) we want to opt for the most concentrated version of whatever steroid(s) we decide we’re going to use. If we’re using Testosterone, we surely want to use a 200mg/ml enanthate over something like 100mg enanthate. If we’re using nandrolone, we want to use 300mg/ml stuff over 50mg/ml or 100mg/ml nandrolone decanoate.
Reference
The Journal of Pharmacology And Experimental Therapeutics, Vol 281, No. 1; 93-102, 1997.
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