To highlight the superiority of methylcobalamin, let's take a look at one study specifically evaluating the effects of methylcobalamin versus cyanocobalamin on circadian rhythms, well-being, alertness, and concentration in healthy subjects.1 The twenty subjects (mean age 36 years) were randomly assigned to treatment for 14 days with 3 mg cyanocobalamin or methylcobalamin after 9 days. The results indicated a significant advantage for methylcobalamin. Methylcobalamin supplementation led to a significantly improved sleep quality, shorter sleep cycles, increased feelings of alertness, better concentration, and a feeling of waking up refreshed in the morning. Some of the interesting findings included the fact that methylcobalamin was significantly more effective even though blood levels of cobalamin increased more significantly in the cyanocobalamin than the methylcobalamin group. Clearly, this finding indicates that methycobalamin is much more biologically active than cyanocobalamin.
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