''palumboism''?

[napoleon]

Ik zat te researchen over HGH toen ik dit tegen kwam.

Diagnosing Palumboism - Sicktracks.com Forums

Blijkbaar is het zo dat je door misbruik van HGH terug evolueert naar de aapmens

@ their prime
http://www.getbig.com/boards/index.php?action=dlattach;topic=26737.0;attach=28696;image

http://www.getbig.com/boards/index.php?action=dlattach;topic=26737.0;attach=28770;image


after:
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''Obviously these two men had excellent arms and legs prior to the development of this "disease." They both suffer from similar jawline and changes in facial structures as well as cyst-like bumps under their skin. Notice how aged they look in those photos, almost like they are over 50 years old (esp. Kovacs). If you look at more recent pictures of Kovacs, his gut is enormous which would back up the theory that his receptors in his gut are hyperactive.

We all know that IGF receptors are concentrated in the intenstines, so if they are shut down elsewhere in the body any IGF injected or just naturally produced gets taken up right there.

Some other theories exsist regarding fat distribution, noticing how the torso seems to take on a lot of viceral fat while the arms/legs are cut up. This could be backed up by the following:
http://www.smj.org.sa/PDFFiles/Nov04...on20040120.pdf

All in all, this ailment is very interesting and I believe that in the future we will see more GH/IGF/Insulin abusers develop this cro-magnon physique''

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[napoleon]

advanced Palumboism the outer dermis takes on a crackly brittle look, almost as if the patient has been glazed or varnished like a ceramic souvenier. The color of the skin will become uneven displaying varying hues and shades from grey to bright orange throughout the entire body, whilst the skin may appear weathered and abnormally aged.



There may also be a high level of vascular distension which never seems to go away in the patient, this will often result in veins having a 'worn out' apperance.

Perhaps the most unusual and distressing issue is that the patient seems totally unaware of what is happening to him.

Post mortem examination of patients sometimes reveals large quantities of a foreign oil-like substance in the biceps and anterior deltoid muscle heads.


What causes Palumboism ?

It is not fully known what causes the disease, although it is speculated that a genetic predisposition combined with an over reliance on high and never ending doses of various anabolic drugs accompanied by a gradual 'shut down' or mutation of the patient's own endiginous endocrine system possibly awakening dormant cro-magnonesque genes are causative factors.

Although Palumboism shares some symptoms with Acromegaly it should not be confused due to the additional conditions described above when making a diagnosis.


Treatments

There is no known cure for Palumboism, as long as the patient remains on his drug regimen there is little comfort and the condition will continue to deteriorate.

Promptly discontinuing drug use may halt further development of the condition although it cannot be fully reversed.

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[napoleon]

excessive use of GH in particular causes a great degree of fat cell death, but a certain amount of fat is necessary to live, so palumboism is the adaptation. severe gh abuse also leads to some amount of insulin resistance(which may be related to the changes in fat cells), another known part of the cause of lipodystrophy. hyperlipidemia from androgens wouldn't help. this would all mirror the lipoatrophy seen from PI and HAART, but with a different cause; in fact, part of the treatment for that form is, ironically, GH itself.

so the net effect of the lipoatrophy and lipogenesis would be the division and creation of the more hardy fat cells centrally located, as well as a loss of intra-muscular and peripheral fat. some bodybuilders try to make up for this with large amounts of site oil (palumbo). muscle groups where this can't be done well turn to twigs (forearms, thighs).

the so-called GH gut is probably more directly caused by slin and LR3IGF-I in serious dosages. GH in particular actually can reduce the gut(at lower dosages) via downregulation of PPARgamma expression. this same downregulation is part of what kills fat cells off. LR3IGF-I increases muscle sensitivity and doesn't fiddle with the PPARgamma receptor like that; in fact, it can cause expression of PPARg mRNA. so, it wouldn't cause palumboism the same way GH would, but it will lead to greater intestinal hyperplasia and hypertrophy.

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een andere theorie.



[Afbeelding niet meer beschikbaar] final stage, lol

 

[koen85]

Wat een lelijke batAAP

 

[luke1984]

Intressant! Wij zien er inderdaad zo uit als we nu doen omdaat onze HGH en Test levels veel lager zijn dan die van onze voorouders omdat wij in een beschermde omgeving leven. Dus als je de hormoonverhoudingen in je lichaam brengt naar het niveau van oermensen, verander je in een "oermens"

 

[Man-Mountain]

dat was een groot broodje aap verhaal van dacht 3 jaar geleden

 

[The phenom]

dat was een groot broodje aap verhaal van dacht 3 jaar geleden

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zou het? volgens mij is het niet zo oud hoor

 

[dennis999]

Dus als je de hormoonverhoudingen in je lichaam brengt naar het niveau van oermensen, verander je in een "oermens"

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hahahahahaha. een oermens...ik moet oppassen, verander ook langzaam in een 'oermens'

 

[napoleon]

hahahahahaha. een oermens...ik moet oppassen, verander ook langzaam in een 'oermens'

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haha maak je geen zorgen joh, wat jij gebruikt is kinderspel vergeleken met wat die gasten gebruiken

 

[redhead]

Das was een broodje oermens verhaal inderdaad.Toendertijd hoorde je verhalen van mensen die krom begonnen te lopen en overal haar kregen na gebruik van hgh.
Ook hoorde je verhalen dat ze moesten janken als weerwolven bij volle maan.....
Oh nee dat was een ander fabeltje

 

[Mans]

Dave Palumbo is een uiterst lelijke bodybuilder die er met de jaren alleen maar op achteruit is gegaan. Die gast lijkt op een mislukt chemisch experiment en daar komt de term vandaan.

 

[Ectobastard]

Misschien een interressant stukje:

ABC News: Real-Life Incredible Hulk

"In this particular case, a tumor went wild and over-produced this one unusual hormone which is an insulin-like growth hormone," Zwischenberger said.

That's why Larry's symptoms appeared like he had taken an excessive amount of growth hormone.