Little Daddy
Monstrous Giant
- Lid sinds
- 8 apr 2010
- Berichten
- 12.100
- Waardering
- 711
Hallo, sinds ik net begon met liften had ik ''vrouwenborsten'', heb alles wegweten te werken maar sinds een jaar heb ik pijn bij m'n borsten, het is 100 % klierweefsel.
Heb nooit gekuurt en ben nu 20 jaar en het doet steeds erger pijn, ben naar een endo doorverwezen maar volgens mij had zij haar diploma ergens gekocht want ze wist er niks van en zei dat het normaal is bij een man (ook de pijn) Nu lopen sukkelen en maandag weer bellen naar mijn huisarts.
Aangezien het pijndoet kan het dit zijn : If you note a very slight inflammation and tenderness to your nipples while using hormonal products, do not be alarmed. It is very possible estrogen has become bound to ERs under your nipples, but this is not necessarily Gynecomastia.
Gyno is niet groot maar heel erg pijnlijk, ik kan serms proberen of voor een operatie maar wil wel onder begeleiding van een specialist het doen. Kwam dit tegen :
Kan SERMS me helpen? En weet iemand of er een specialist is dat het me wil voorschrijven en controleren? Heb het al een jaar lang maar nu is het echt erg dat ik me eraan erger.
M'n bloedwerk was ''ok'' volgens haar btw ook een echo gemaakt en was ook ''ok''
Heb nooit gekuurt en ben nu 20 jaar en het doet steeds erger pijn, ben naar een endo doorverwezen maar volgens mij had zij haar diploma ergens gekocht want ze wist er niks van en zei dat het normaal is bij een man (ook de pijn) Nu lopen sukkelen en maandag weer bellen naar mijn huisarts.
Aangezien het pijndoet kan het dit zijn : If you note a very slight inflammation and tenderness to your nipples while using hormonal products, do not be alarmed. It is very possible estrogen has become bound to ERs under your nipples, but this is not necessarily Gynecomastia.
Gyno is niet groot maar heel erg pijnlijk, ik kan serms proberen of voor een operatie maar wil wel onder begeleiding van een specialist het doen. Kwam dit tegen :
A quick research search will reveal that invasive surgery is regarded as the only manner to remove permanent glandular tissue; however, recent studies have revealed the use of aromatase inhibitors such as Letrozole, or SERMs such as Tamoxifen Citrate, can eradicate proliferated glandular tissue.
In cases of long or unknown duration, or where macromastia beyond increased glandular tissue is noted, surgery is almost always required. With that being said, most treatment centers and studies noted that tissue under 36 months duration can be treated non-surgically.
The two most common classes of Gynecomastia treatments are SERMs (Selective Estrogen Receptor Modulators) which are breast-specific, and AI (Aromatase Inhibitors) which are systemic, and lower serum levels of E1 and E2.
The most common SERMs are:
Tamoxifen
Raloxifen
Toremifene
Clomid
The most common Aromatase Inhibitors are:
Letrozole
Anastrozole
Literature on several of the above mentioned compounds.
Tamoxifen treatment for pubertal gynecomastia
By Derman O, Kanbur NO, K*tluk T.
Section of Adolescent Medicine, Department of Pediatrics,
Hacettepe University Faculty of Medicine, 06100 Ankara-Turkey.
We evaluated the efficacy of the tamoxifen treatment in 37 patients with pubertal gynecomastia. All had distinct, easily palpable breast swellings with a diameter of over three cm. Pain, tenderness, and swelling associated with gynecomastia were reported by six patients. Eight of the patients were obese. One patient also suffered from varicocele. Pain and size reduction was seen in all patients with tamoxifen treatment. No long-term side effects of tamoxifen were observed. The dose of tamoxifen was increased in three patients due to poor response. Two of the treatment group had recurrence problem at follow-up. We did not need to refer any patient to surgery. Tamoxifen treatment is relatively non-toxic, may be beneficial and we think it should be considered for pubertal gynecomastia.
1: J Pediatr. 2004 Jul;145(1):71-6. Related Articles, Links
Comment in:
* J Pediatr. 2005 Apr;146(4):576; author reply 576-7.
* J Pediatr. 2005 Apr;146(4):576; author reply 576-7.
Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.
Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.
Department of Pediatrics, University of Ottawa, Ontario, Canada.
OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifene in the medical management of persistent pubertal gynecomastia.
STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene).
RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients.
CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.
PMID: 15238910 [PubMed - indexed for MEDLINE]
Treatment of Pubertal Gynecomastia with the Specific Aromatase Inhibitor Anastrozole
Felix G. Riepe, Inka Baus, Stephanie Wiest, Nils Krone, Wolfgang G. Sippell, Carl-Joachim Partsch
Division of Pediatric Endocrinology, Department of Paediatrics, Christian-Albrechts-Universität Kiel, Kiel, Germany
Horm Res 2004;62:113-118 (DOI: 10.1159/000079882)
Abstract
Gynecomastia can be detected in up to 70% of boys during puberty and in about one third of adult males. An imbalance of estrogen to androgen tissue levels is believed to be the major reason for the development of gynecomastia; as a result most medical treatments so far have tried to lower the estrogen level. Five boys with pubertal gynecomastia and breast tenderness were treated for 6 months with the selective aromatase inhibitor anastrozole. Initial plasma levels of estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone sulfate (DHEA-S) and gonadotropins were normal. DHEA-S showed a significant rise during treatment. T and androstenedione showed no significant change during treatment. E2 decreased with therapy, although to no statistically significant extent. The E2/T ratio decreased significantly during the treatment. Breast size decreased in 4 out of 5 patients, and in 1 of these 4 boys glandular breast tissue disappeared completely. The longer the duration of gynecomastia before anastrozole administration, the smaller was the reduction of breast size. Breast tenderness was resolved in all boys within 4 weeks. No adverse effects were recorded. Since the aim of medical treatment is the total disappearance of breast tissue, anastrozole, as previous aromatase inhibitors, is of limited effect. However, anastrozole seems to be of benefit for the treatment of tenderness in gynecomastia and for patients in whom surgery is particularly risky. However, as spontaneous disappearance of pubertal gynecomastia is common, further double-blinded, placebo-controlled trials are necessary before a definite conclusion can be drawn about the effectiveness and the side effects of this therapy.
BCS: Femara (Letrozole) Significantly More Effective Than Tamoxifen In Treating Advanced Breast Cancer
"Letrozole was consistently more effective than tamoxifen in the advanced disease setting. It was very satisfying to observe significantly improved outcomes with letrozole in the preoperative trial as well," said Matthew Ellis, MD, Ph.D., FRCP, Clinical Director, Duke Breast Cancer Program, Duke University Medical Center and lead investigator in the pre-operative study. "These data will provide great impetus for the ongoing letrozole adjuvant trials and underscore the potential of letrozole to benefit thousands of postmenopausal women with breast cancer every year."
This study of more than 900 women compared the efficacy of Femara and tamoxifen as first-line treatment for advanced breast cancer. The results demonstrate that Femara delays progression of advanced breast cancer for 9.4 months, as compared to 6.0 months for tamoxifen (41 weeks vs. 26 weeks). Results also indicate significant differences between Femara and tamoxifen with respect to overall tumor response rates (30 percentvs. 20 percent), clinical benefit (49 percent vs. 38 percent) and time to treatment failure (9.1 months vs. 5.7 months, or 40 weeks vs. 25 weeks).
The women enrolled in this phase III randomized, double blind multi-center trial were postmenopausal with either locally advanced (stage IIIB) disease, or metastatic breast cancer, or had recurrences not amenable to treatment with surgery or radiotherapy.
In this phase III randomized, controlled trial of 324 postmenopausal women, patients with large localized or locally advanced breast cancer tumors were given Femara or tamoxifen as pre-operative treatment for four months to reduce tumor size before surgery. The primary objective was to compare the anti-tumor activity of Femara, an aromatase inhibitor, to that of tamoxifen by measuring clinical tumor response in these patients.
Clinical responses in this study were significantly better for Femara than for tamoxifen (55 percent versus 36 percent). After adjustment for tumor size, nodal involvement and age, the odds of undergoing breast-conserving surgery were increased by more than 70 percent for Femara compared with the odds for tamoxifen.
Bicalumatide is an anti-androgen used in the treatment of Prostate Cancer:
1: J Clin Oncol. 2005 Feb 1;23(4):808-15. Links
Comment in:
J Clin Oncol. 2005 Aug 20;23(24):5845: author reply 5846-7.
Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer.
Boccardo F, Rubagotti A, Battaglia M, Di Tonno P, Selvaggi FP, Conti G, Comeri G, Bertaccini A, Martorana G, Galassi P, Zattoni F, Macchiarella A, Siragusa A, Muscas G, Durand F, Potenzoni D, Manganelli A, Ferraris V, Montefiore F.
University and National Cancer Research Institute, University of Genoa, Genoa, Italy. f.boccardo@unige.it
PURPOSE: To determine whether tamoxifen or anastrozole prevents gynecomastia and breast pain caused by bicalutamide (150 mg) without compromising efficacy, safety, or coïtusual functioning. PATIENTS AND METHODS: A double-blind, placebo-controlled trial was performed in patients with localized, locally advanced, or biochemically recurrent prostate cancer. Patients (N = 114) were randomly assigned to either bicalutamide (150 mg/d) plus placebo or in combination with tamoxifen (20 mg/d) or anastrozole (1 mg/d) for 48 weeks. Gynecomastia, breast pain, prostate-specific antigen (PSA), coïtusual functioning, and serum levels of hormones were assessed. RESULTS: Gynecomastia developed in 73% of patients in the bicalutamide group, 10% of patients in the bicalutamide-tamoxifen group, and 51% of patients in the bicalutamide-anastrozole group (P < .001); breast pain developed in 39%, 6%, and 27% of patients, respectively (P = .006). Baseline PSA level decreased by > or = 50% in 97%, 97%, and 83% of patients in the bicalutamide, bicalutamide-tamoxifen, and bicalutamide-anastrozole groups, respectively (P = .07); and adverse events were reported in 37%, 35%, and 69% of patients, respectively (P = .004). There were no major differences among treatments in coïtusual functioning parameters from baseline to month 6. Elevated testosterone levels occurred in each group; however, free testosterone levels remained unchanged in the bicalutamide-tamoxifen group because of increased coïtus hormone-binding globulin levels. CONCLUSION: Anastrozole did not significantly reduce the incidence of bicalutamide-induced gynecomastia and breast pain. In contrast, tamoxifen was effective, without increasing adverse events, at least in the short-term follow-up. These data support the need for a larger study to determine any effect on mortality.
In cases of long or unknown duration, or where macromastia beyond increased glandular tissue is noted, surgery is almost always required. With that being said, most treatment centers and studies noted that tissue under 36 months duration can be treated non-surgically.
The two most common classes of Gynecomastia treatments are SERMs (Selective Estrogen Receptor Modulators) which are breast-specific, and AI (Aromatase Inhibitors) which are systemic, and lower serum levels of E1 and E2.
The most common SERMs are:
Tamoxifen
Raloxifen
Toremifene
Clomid
The most common Aromatase Inhibitors are:
Letrozole
Anastrozole
Literature on several of the above mentioned compounds.
Tamoxifen treatment for pubertal gynecomastia
By Derman O, Kanbur NO, K*tluk T.
Section of Adolescent Medicine, Department of Pediatrics,
Hacettepe University Faculty of Medicine, 06100 Ankara-Turkey.
We evaluated the efficacy of the tamoxifen treatment in 37 patients with pubertal gynecomastia. All had distinct, easily palpable breast swellings with a diameter of over three cm. Pain, tenderness, and swelling associated with gynecomastia were reported by six patients. Eight of the patients were obese. One patient also suffered from varicocele. Pain and size reduction was seen in all patients with tamoxifen treatment. No long-term side effects of tamoxifen were observed. The dose of tamoxifen was increased in three patients due to poor response. Two of the treatment group had recurrence problem at follow-up. We did not need to refer any patient to surgery. Tamoxifen treatment is relatively non-toxic, may be beneficial and we think it should be considered for pubertal gynecomastia.
1: J Pediatr. 2004 Jul;145(1):71-6. Related Articles, Links
Comment in:
* J Pediatr. 2005 Apr;146(4):576; author reply 576-7.
* J Pediatr. 2005 Apr;146(4):576; author reply 576-7.
Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.
Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.
Department of Pediatrics, University of Ottawa, Ontario, Canada.
OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifene in the medical management of persistent pubertal gynecomastia.
STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene).
RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients.
CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.
PMID: 15238910 [PubMed - indexed for MEDLINE]
Treatment of Pubertal Gynecomastia with the Specific Aromatase Inhibitor Anastrozole
Felix G. Riepe, Inka Baus, Stephanie Wiest, Nils Krone, Wolfgang G. Sippell, Carl-Joachim Partsch
Division of Pediatric Endocrinology, Department of Paediatrics, Christian-Albrechts-Universität Kiel, Kiel, Germany
Horm Res 2004;62:113-118 (DOI: 10.1159/000079882)
Abstract
Gynecomastia can be detected in up to 70% of boys during puberty and in about one third of adult males. An imbalance of estrogen to androgen tissue levels is believed to be the major reason for the development of gynecomastia; as a result most medical treatments so far have tried to lower the estrogen level. Five boys with pubertal gynecomastia and breast tenderness were treated for 6 months with the selective aromatase inhibitor anastrozole. Initial plasma levels of estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone sulfate (DHEA-S) and gonadotropins were normal. DHEA-S showed a significant rise during treatment. T and androstenedione showed no significant change during treatment. E2 decreased with therapy, although to no statistically significant extent. The E2/T ratio decreased significantly during the treatment. Breast size decreased in 4 out of 5 patients, and in 1 of these 4 boys glandular breast tissue disappeared completely. The longer the duration of gynecomastia before anastrozole administration, the smaller was the reduction of breast size. Breast tenderness was resolved in all boys within 4 weeks. No adverse effects were recorded. Since the aim of medical treatment is the total disappearance of breast tissue, anastrozole, as previous aromatase inhibitors, is of limited effect. However, anastrozole seems to be of benefit for the treatment of tenderness in gynecomastia and for patients in whom surgery is particularly risky. However, as spontaneous disappearance of pubertal gynecomastia is common, further double-blinded, placebo-controlled trials are necessary before a definite conclusion can be drawn about the effectiveness and the side effects of this therapy.
BCS: Femara (Letrozole) Significantly More Effective Than Tamoxifen In Treating Advanced Breast Cancer
"Letrozole was consistently more effective than tamoxifen in the advanced disease setting. It was very satisfying to observe significantly improved outcomes with letrozole in the preoperative trial as well," said Matthew Ellis, MD, Ph.D., FRCP, Clinical Director, Duke Breast Cancer Program, Duke University Medical Center and lead investigator in the pre-operative study. "These data will provide great impetus for the ongoing letrozole adjuvant trials and underscore the potential of letrozole to benefit thousands of postmenopausal women with breast cancer every year."
This study of more than 900 women compared the efficacy of Femara and tamoxifen as first-line treatment for advanced breast cancer. The results demonstrate that Femara delays progression of advanced breast cancer for 9.4 months, as compared to 6.0 months for tamoxifen (41 weeks vs. 26 weeks). Results also indicate significant differences between Femara and tamoxifen with respect to overall tumor response rates (30 percentvs. 20 percent), clinical benefit (49 percent vs. 38 percent) and time to treatment failure (9.1 months vs. 5.7 months, or 40 weeks vs. 25 weeks).
The women enrolled in this phase III randomized, double blind multi-center trial were postmenopausal with either locally advanced (stage IIIB) disease, or metastatic breast cancer, or had recurrences not amenable to treatment with surgery or radiotherapy.
In this phase III randomized, controlled trial of 324 postmenopausal women, patients with large localized or locally advanced breast cancer tumors were given Femara or tamoxifen as pre-operative treatment for four months to reduce tumor size before surgery. The primary objective was to compare the anti-tumor activity of Femara, an aromatase inhibitor, to that of tamoxifen by measuring clinical tumor response in these patients.
Clinical responses in this study were significantly better for Femara than for tamoxifen (55 percent versus 36 percent). After adjustment for tumor size, nodal involvement and age, the odds of undergoing breast-conserving surgery were increased by more than 70 percent for Femara compared with the odds for tamoxifen.
Bicalumatide is an anti-androgen used in the treatment of Prostate Cancer:
1: J Clin Oncol. 2005 Feb 1;23(4):808-15. Links
Comment in:
J Clin Oncol. 2005 Aug 20;23(24):5845: author reply 5846-7.
Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer.
Boccardo F, Rubagotti A, Battaglia M, Di Tonno P, Selvaggi FP, Conti G, Comeri G, Bertaccini A, Martorana G, Galassi P, Zattoni F, Macchiarella A, Siragusa A, Muscas G, Durand F, Potenzoni D, Manganelli A, Ferraris V, Montefiore F.
University and National Cancer Research Institute, University of Genoa, Genoa, Italy. f.boccardo@unige.it
PURPOSE: To determine whether tamoxifen or anastrozole prevents gynecomastia and breast pain caused by bicalutamide (150 mg) without compromising efficacy, safety, or coïtusual functioning. PATIENTS AND METHODS: A double-blind, placebo-controlled trial was performed in patients with localized, locally advanced, or biochemically recurrent prostate cancer. Patients (N = 114) were randomly assigned to either bicalutamide (150 mg/d) plus placebo or in combination with tamoxifen (20 mg/d) or anastrozole (1 mg/d) for 48 weeks. Gynecomastia, breast pain, prostate-specific antigen (PSA), coïtusual functioning, and serum levels of hormones were assessed. RESULTS: Gynecomastia developed in 73% of patients in the bicalutamide group, 10% of patients in the bicalutamide-tamoxifen group, and 51% of patients in the bicalutamide-anastrozole group (P < .001); breast pain developed in 39%, 6%, and 27% of patients, respectively (P = .006). Baseline PSA level decreased by > or = 50% in 97%, 97%, and 83% of patients in the bicalutamide, bicalutamide-tamoxifen, and bicalutamide-anastrozole groups, respectively (P = .07); and adverse events were reported in 37%, 35%, and 69% of patients, respectively (P = .004). There were no major differences among treatments in coïtusual functioning parameters from baseline to month 6. Elevated testosterone levels occurred in each group; however, free testosterone levels remained unchanged in the bicalutamide-tamoxifen group because of increased coïtus hormone-binding globulin levels. CONCLUSION: Anastrozole did not significantly reduce the incidence of bicalutamide-induced gynecomastia and breast pain. In contrast, tamoxifen was effective, without increasing adverse events, at least in the short-term follow-up. These data support the need for a larger study to determine any effect on mortality.
Kan SERMS me helpen? En weet iemand of er een specialist is dat het me wil voorschrijven en controleren? Heb het al een jaar lang maar nu is het echt erg dat ik me eraan erger.
M'n bloedwerk was ''ok'' volgens haar btw ook een echo gemaakt en was ook ''ok''
)
