Little Me
Competitive Bodybuilder
- Lid sinds
- 21 jun 2005
- Berichten
- 2.664
- Waardering
- 1
verschillen tussen sth, hgh, igf 1, hcg...
- Topic starter ikke 20
- Startdatum
- Recente activiteit Recente activiteit:
- Reacties 30
- Weergaven 3.058
- Volgers 2
-
- Tags
- groeihormoon hcg hgh igf-1 sth
- Lid sinds
- 13 jan 2003
- Berichten
- 2.268
- Waardering
- 6
Little Me
Competitive Bodybuilder
- Lid sinds
- 21 jun 2005
- Berichten
- 2.664
- Waardering
- 1
IKKE zei:
Ok daar ben ik het mee eens , ik doelde eerder op na jarenlang trainen .
- Lid sinds
- 13 jan 2003
- Berichten
- 2.268
- Waardering
- 6
SCREWBEAST
Freaky Bodybuilder
- Lid sinds
- 15 mrt 2004
- Berichten
- 5.077
- Waardering
- 220
- Lengte
- 1m85
- Massa
- 97kg
- Vetpercentage
- 12%
- Lid sinds
- 13 jan 2003
- Berichten
- 2.268
- Waardering
- 6
- Lid sinds
- 11 mrt 2004
- Berichten
- 8.400
- Waardering
- 121
- Lengte
- 1m83
- Massa
- 110kg
- Lid sinds
- 13 jan 2003
- Berichten
- 2.268
- Waardering
- 6
- Lid sinds
- 8 mei 2003
- Berichten
- 3.620
- Waardering
- 29
- Lid sinds
- 13 jan 2003
- Berichten
- 2.268
- Waardering
- 6
- Lid sinds
- 8 mei 2003
- Berichten
- 3.620
- Waardering
- 29
Approximately 95% of the IGF-I and IGF-II are bound to IGFBP-3, which makes this protein the major carrier of IGFs in plasma. One of the principal functions of binding proteins is to extend the half-life of the IGFs from eight minutes to several hours. In this way, IGFBP-3 acts as a stabilizer, providing a constant level of IGF. The serum level of IGFBP-3 appears to be a constant over 24 hours and the protein was found to be growth hormone (GH) dependent, which makes the detection of IGFBP-3 very useful in the evaluation of growth hormone secretion. Single IGFBP-3 measurements correlate significantly with the logarithm of the integrated spontaneous GH secretions.
Advantages of IGFBP-3 over IGF-1 are the higher levels in young children which gives a better discrimination between normal and subnormal levels. The IGFBP-3 assay is also used to diagnose children with short stature having normal GH levels. Some children with short stature give subnormal IGF- I levels despite normal GH levels. IGFBP-3 was found to be a more reliable parameter for monitoring the efficacy of therapy. Therefore, it is a useful adjunct to the measurement of IGF-I.
Limitations
Several factors influence IGFBP-3 levels including age, coïtusual development, nutrition, and hepatic and renal function. IGFBP-3 increases during early childhood and puberty and then decreases slightly in adult life. Levels of this binding protein decrease during fasting and chronic malnutrition. IGFBP-3 levels are decreased in hepatic failure and diabetes mellitus, but are increased in chronic renal failure.
Methodology
Immunochemiluminometric Assay (ICMA)
Footnotes
1. Nichols Institute Diagnostics (kit manufacturer) Directional Insert
References
Baxter RC, Martin JL. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma. J Clin Invest. 1986; 78(6):1504-1512.
Blum WF, Ranke MB, Kietzmann K, et al. A specific radioimmunoassay for the growth hormone (GH)- dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency. J Clin Endocrinol Metab. 1990; 70(5):1292-1298.
Rosenfeld RG, Wilson DM, Lee PDK, et al. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr. 1986; 109(3):428-433"
Advantages of IGFBP-3 over IGF-1 are the higher levels in young children which gives a better discrimination between normal and subnormal levels. The IGFBP-3 assay is also used to diagnose children with short stature having normal GH levels. Some children with short stature give subnormal IGF- I levels despite normal GH levels. IGFBP-3 was found to be a more reliable parameter for monitoring the efficacy of therapy. Therefore, it is a useful adjunct to the measurement of IGF-I.
Limitations
Several factors influence IGFBP-3 levels including age, coïtusual development, nutrition, and hepatic and renal function. IGFBP-3 increases during early childhood and puberty and then decreases slightly in adult life. Levels of this binding protein decrease during fasting and chronic malnutrition. IGFBP-3 levels are decreased in hepatic failure and diabetes mellitus, but are increased in chronic renal failure.
Methodology
Immunochemiluminometric Assay (ICMA)
Footnotes
1. Nichols Institute Diagnostics (kit manufacturer) Directional Insert
References
Baxter RC, Martin JL. Radioimmunoassay of growth hormone-dependent insulin-like growth factor binding protein in human plasma. J Clin Invest. 1986; 78(6):1504-1512.
Blum WF, Ranke MB, Kietzmann K, et al. A specific radioimmunoassay for the growth hormone (GH)- dependent somatomedin-binding protein: Its use for diagnosis of GH deficiency. J Clin Endocrinol Metab. 1990; 70(5):1292-1298.
Rosenfeld RG, Wilson DM, Lee PDK, et al. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr. 1986; 109(3):428-433"
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