vitamine b6 50mg/ml
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Existing authorisations and valuations vary considerably worldwide. In 1993, the European Community Scientific Committee on Food defined intakes of 50 mg of vitamin B6 per day as harmful and established a tolerable upper intake level of 25 mg/day for adults in 2000.
The Expert Group on Vitamins and Minerals of the Food Standard Agency UK (UK EVM) derived a safe upper level (SUL) of 10 mg/day for a 60-kg adult in 2003
The tolerable upper limit has been set by the US FDA at 100 mg/day in 2000.[22] The nutrient reference values in Australia and New Zealand recommend an upper limit of 50 mg a day in adults.
"The same figure was set for pregnancy and lactation as there is no evidence of teratogenicity at this level. The UL was set based on metabolic body size and growth considerations for all other ages and life stages except infancy. It was not possible to set a UL for infants, so intake is recommended in the form of food, milk or formula." "The ULs were set using results of studies involving long-term oral administration of pyridoxine at doses of less than 1g/day (Berger & Schaumburg 1984, Bernstein & Lobitz 1988, Dalton 1985, Dalton & Dalton 1987, Del Tredici et al 1985, FNB:IOM 1998, Parry & Bredesen 1985). A NOAEL of 200 mg/day was identified from the studies of Bernstein & Lobitz (1988) and Del Tredici et al (1985). These studies involved subjects who had generally been on the supplements for five to six months or less. The study of Dalton and Dalton (1987), however, suggested the symptoms might take substantially longer than this to appear. In this latter retrospective survey, subjects who reported symptoms had been on supplements for 2.9 years, on average. Those reporting no symptoms had taken supplements for 1.9 years."[23]
Because no placebo-controlled studies show therapeutic benefits of high doses of pyridoxine, and the well-documented occurrence of significant toxic effects, there is little reason to exceed the RDI using supplements unless under medical supervision e.g. in treatment of primary hyperoxaluria.
http://en.wikipedia.org/wiki/Vitamin_B6
http://www.efsa.europa.eu/en/scdocs/doc/afc_ej760_pyridoxal_op_en,0.pdf?ssbinary=true
---------- Post toegevoegd Fri 20 Jul 2012 om 00:27 ----------
http://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
The FNB has established ULs for vitamin B6 that apply to both food and supplement intakes (Table 3) [1]. The FNB noted that although several reports show sensory neuropathy occurring at doses lower than 500 mg/day, studies in patients treated with vitamin B6 (average dose of 200 mg/day) for up to 5 years found no evidence of this effect. Based on limitations in the data on potential harms from long-term use, the FNB halved the dose used in these studies to establish a UL of 100 mg/day for adults. ULs are lower for children and adolescents based on body size. The ULs do not apply to individuals receiving vitamin B6 for medical treatment, but such individuals should be under the care of a physician.
Ik zou voor zekerheid aan max 25mg/dag houden. Gezien dit als zekere veilige bovengrens wordt beschouwd. De ADH is 1,5mg, dus met 25 mg heb je meer dan genoeg binnen.
http://www.vitamine-info.nl/alle-vitamines-en-mineralen-op-een-rij/vitamine-b6/
The Expert Group on Vitamins and Minerals of the Food Standard Agency UK (UK EVM) derived a safe upper level (SUL) of 10 mg/day for a 60-kg adult in 2003
The tolerable upper limit has been set by the US FDA at 100 mg/day in 2000.[22] The nutrient reference values in Australia and New Zealand recommend an upper limit of 50 mg a day in adults.
"The same figure was set for pregnancy and lactation as there is no evidence of teratogenicity at this level. The UL was set based on metabolic body size and growth considerations for all other ages and life stages except infancy. It was not possible to set a UL for infants, so intake is recommended in the form of food, milk or formula." "The ULs were set using results of studies involving long-term oral administration of pyridoxine at doses of less than 1g/day (Berger & Schaumburg 1984, Bernstein & Lobitz 1988, Dalton 1985, Dalton & Dalton 1987, Del Tredici et al 1985, FNB:IOM 1998, Parry & Bredesen 1985). A NOAEL of 200 mg/day was identified from the studies of Bernstein & Lobitz (1988) and Del Tredici et al (1985). These studies involved subjects who had generally been on the supplements for five to six months or less. The study of Dalton and Dalton (1987), however, suggested the symptoms might take substantially longer than this to appear. In this latter retrospective survey, subjects who reported symptoms had been on supplements for 2.9 years, on average. Those reporting no symptoms had taken supplements for 1.9 years."[23]
Because no placebo-controlled studies show therapeutic benefits of high doses of pyridoxine, and the well-documented occurrence of significant toxic effects, there is little reason to exceed the RDI using supplements unless under medical supervision e.g. in treatment of primary hyperoxaluria.
http://en.wikipedia.org/wiki/Vitamin_B6
http://www.efsa.europa.eu/en/scdocs/doc/afc_ej760_pyridoxal_op_en,0.pdf?ssbinary=true
---------- Post toegevoegd Fri 20 Jul 2012 om 00:27 ----------
http://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
The FNB has established ULs for vitamin B6 that apply to both food and supplement intakes (Table 3) [1]. The FNB noted that although several reports show sensory neuropathy occurring at doses lower than 500 mg/day, studies in patients treated with vitamin B6 (average dose of 200 mg/day) for up to 5 years found no evidence of this effect. Based on limitations in the data on potential harms from long-term use, the FNB halved the dose used in these studies to establish a UL of 100 mg/day for adults. ULs are lower for children and adolescents based on body size. The ULs do not apply to individuals receiving vitamin B6 for medical treatment, but such individuals should be under the care of a physician.
Ik zou voor zekerheid aan max 25mg/dag houden. Gezien dit als zekere veilige bovengrens wordt beschouwd. De ADH is 1,5mg, dus met 25 mg heb je meer dan genoeg binnen.
http://www.vitamine-info.nl/alle-vitamines-en-mineralen-op-een-rij/vitamine-b6/
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