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effectiviteit van exogeen HGH bij jonge mannen
- Topic starter rusher
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- groeihormoon hgh mannen
rusher
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en hoe weten de heren dan evt. gains door de HGH komen? mss waren het wel natural gains (bij HGH only)? vaak wordt er test en andere zooi naast gezet wat het resultaat natuurlijk beinvloed.
ik zeg trouwens niet dat dat het niet zo zou zijn, maar het zou best aardig zijn als het in studies bevestigd zou worden.
ik zeg trouwens niet dat dat het niet zo zou zijn, maar het zou best aardig zijn als het in studies bevestigd zou worden.
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nee, had t tegen jou
ga je een logje bijhouden MHD?
Misschien, weet ook nog niet goed wanneer ik ga beginnen.
Miss Deadlift
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Regel 1 van expression profiling:
Genes not altered may be important
Genes altered may not be important
met andere woorden ben niet overtuigd
moet wel zeggen dat ik het idee om het niet te nemen als je er zelf nog zat van hebt wel voor de hand vind liggen verder maar om dan maar gelijk te zeggen dat het geen effect heeft nee..en dat blijkt hier ook niet direct uit. In de spiercellen word niet meer igf-1 tot expressie gebracht maar in de lever wel nou en daarvandaan komt het dus lekker in de circulatie terecht en kan binden aan de receptoren op de spieren en dus gewoon werken, toch?
ow..
Waarom werkt het alleen als het in de spier zelf gemaakt is dan?
Genes not altered may be important
Genes altered may not be important
met andere woorden ben niet overtuigd
moet wel zeggen dat ik het idee om het niet te nemen als je er zelf nog zat van hebt wel voor de hand vind liggen verder maar om dan maar gelijk te zeggen dat het geen effect heeft nee..en dat blijkt hier ook niet direct uit. In de spiercellen word niet meer igf-1 tot expressie gebracht maar in de lever wel nou en daarvandaan komt het dus lekker in de circulatie terecht en kan binden aan de receptoren op de spieren en dus gewoon werken, toch?
ow..
heb ik toch nog zitten pitten dan..rusher zei:
Waarom werkt het alleen als het in de spier zelf gemaakt is dan?
rusher
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mn uitspraak was ietwat ongenuanceerd
Metabolic functions of liver-derived (endocrine) insulin-like growth factor I.
Isaksson OG, Jansson JO, Sjogren K, Ohlsson C.
RCEM, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden. Isaksson@medic.gu.se
Until now it has been difficult to determine the relative importance of locally produced (autocrine/paracrine) versus systemically derived (endocrine) insulin-like growth factor I (IGF-I) in the intact organism. We recently eliminated IGF-I production in the livers of mice using the Cre/loxP recombination system. These mice displayed a reduction in serum IGF-I levels of more than 80%, but demonstrated normal body growth, suggesting that autocrine/paracrine-acting IGF-I, but not endocrine-acting IGF-I, regulates body growth. Long-term metabolic studies of mice in which IGF-I production had been inactivated in the liver, have shown that the mice have decreased fat mass, but increased serum levels of insulin and cholesterol. Despite the marked increase in plasma insulin following glucose administration, the glucose elimination was not altered in these animals. Thus, the mice showed an adequately compensated insulin resistance. In conclusion, liver-derived or endocrine IGF-I is not required for post-natal statural growth, but seems to be of vital importance for normal carbohydrate and lipid metabolism. Copyright 2001 S. Karger AG, Basel
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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
Klara Sjögren*,, Jun-Li Liu, Kristina Blad*, Stanko Skrtic*, Olle Vidal*, Ville Wallenius*, Derek LeRoith, Jan Törnell, Olle G. P. Isaksson*,§, John-Olov Jansson*, and Claes Ohlsson
Metabolic functions of liver-derived (endocrine) insulin-like growth factor I.
Isaksson OG, Jansson JO, Sjogren K, Ohlsson C.
RCEM, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden. Isaksson@medic.gu.se
Until now it has been difficult to determine the relative importance of locally produced (autocrine/paracrine) versus systemically derived (endocrine) insulin-like growth factor I (IGF-I) in the intact organism. We recently eliminated IGF-I production in the livers of mice using the Cre/loxP recombination system. These mice displayed a reduction in serum IGF-I levels of more than 80%, but demonstrated normal body growth, suggesting that autocrine/paracrine-acting IGF-I, but not endocrine-acting IGF-I, regulates body growth. Long-term metabolic studies of mice in which IGF-I production had been inactivated in the liver, have shown that the mice have decreased fat mass, but increased serum levels of insulin and cholesterol. Despite the marked increase in plasma insulin following glucose administration, the glucose elimination was not altered in these animals. Thus, the mice showed an adequately compensated insulin resistance. In conclusion, liver-derived or endocrine IGF-I is not required for post-natal statural growth, but seems to be of vital importance for normal carbohydrate and lipid metabolism. Copyright 2001 S. Karger AG, Basel
--
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
Klara Sjögren*,, Jun-Li Liu, Kristina Blad*, Stanko Skrtic*, Olle Vidal*, Ville Wallenius*, Derek LeRoith, Jan Törnell, Olle G. P. Isaksson*,§, John-Olov Jansson*, and Claes Ohlsson
rusher
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Nog een interessant stukje:
Title:Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function
Researchers: Elisabeth R. Barton-Davis*, Daria I. Shoturma*, Antonio Musaro, Nadia Rosenthal, and H. Lee Sweeney*,
* Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA and Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA
Source: Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15603-7
Analyse door Brian Haycock:
IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the blood stream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, but in addition can stimulate protein synthesis. The insulin-like effects are probably due to the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.
The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is often believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1 concentrations. Age related muscle loss has been prevented with GH injections, however it is believed that this is accomplished through IGF-1.
The results of this study are similar to other studies where IGF-1 was injected directly into muscle tissue, resulting in increases in size and strength of experimental animals. Using a virus as a genetic vehicle has an advantage over simply injecting the growth factor. The effects of a single viral treatment last significantly longer (months if not years) because the muscle cell itself is constantly overproducing its own IGF-1 from injected DNA.
The fact that the IGF-1 produced by the muscle of these mice did not reach the blood stream is interesting. Systemic injections of IGF-1 have not been successful in inducing this kind of anabolic effect in humans. In addition, IGF-1 produced by the liver is genetically different than that produced by muscle tissue. It could be that providing additional DNA for the muscle to produce it’s own IGF-1 is the key to achieving anabolic and rejuvenative effects specifically in skeletal muscle.
Title:Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function
Researchers: Elisabeth R. Barton-Davis*, Daria I. Shoturma*, Antonio Musaro, Nadia Rosenthal, and H. Lee Sweeney*,
* Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA and Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA
Source: Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15603-7
Analyse door Brian Haycock:
IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the blood stream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, but in addition can stimulate protein synthesis. The insulin-like effects are probably due to the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.
The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is often believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1 concentrations. Age related muscle loss has been prevented with GH injections, however it is believed that this is accomplished through IGF-1.
The results of this study are similar to other studies where IGF-1 was injected directly into muscle tissue, resulting in increases in size and strength of experimental animals. Using a virus as a genetic vehicle has an advantage over simply injecting the growth factor. The effects of a single viral treatment last significantly longer (months if not years) because the muscle cell itself is constantly overproducing its own IGF-1 from injected DNA.
The fact that the IGF-1 produced by the muscle of these mice did not reach the blood stream is interesting. Systemic injections of IGF-1 have not been successful in inducing this kind of anabolic effect in humans. In addition, IGF-1 produced by the liver is genetically different than that produced by muscle tissue. It could be that providing additional DNA for the muscle to produce it’s own IGF-1 is the key to achieving anabolic and rejuvenative effects specifically in skeletal muscle.
Goed stukje, enkel gaat het over jonge mannen wie zegt dat deze jonge mannen niet/wel trainen? Als ze als bodybuilders trainen zal de gevoeligheid voor IGF in de spieren veelal flink toenemen.
Enige onderzoek wat je kan doen om te weten wat werkt voor jou is nog altijd op jezelf. Onderzoeken kunnen je enkel een indicatie geven wat het doet en of het (on)gezond is.
Enige onderzoek wat je kan doen om te weten wat werkt voor jou is nog altijd op jezelf. Onderzoeken kunnen je enkel een indicatie geven wat het doet en of het (on)gezond is.
