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Tibolone

Bezoekers in dit topic

Wolfyy

Cool Novice
Lid geworden
3 mrt 2018
Berichten
72
Waardering
26
Lengte
1m50
Massa
40kg
Vetpercentage
50%
Iemand ervaring met dit middel? Wordt voornamelijk door vrouwen als HRT in de menopauze gebruikt.
Verkrijgbaar onder de naam Livial. Heeft een anabolische, progestogene en oestrogene werking

Different effects of tibolone and continuous combined estrogen plus progestogen hormone therapy on sex hormone binding globulin and free testostero... - PubMed - NCBI

In contrast, tibolone had only a minor influence on circulating estrogens. Sex hormone binding globulin (SHBG) levels were reduced by 50%, while levels of androgens increased. Baseline values of estrone sulfate (E1S), around 1.0-1.1 nmol/l, were increased to 44.7 nmol/l by E2/NETA and to only 1.7 nmol/l by tibolone (p < 0.001). Mammographic breast density displayed a negative correlation with age and body mass index and a positive association with SHBG. After 6 months there was also a negative correlation with levels of free testosterone. Conclusion We found that tibolone and E2/NETA caused distinct differences in estrogen/androgen status and blood levels of possible breast mitogens. The negative association between free testosterone and mammographic density could be a possible explanation for tibolone having less influence on the breast.

Postmenopausal HRT and tibolone in relation to muscle strength and body composition. - PubMed - NCBI

Three of five randomized controlled trials reported a significant positive effect of HRT on muscle strength but not on body composition. Tibolone significantly increased handgrip strength and isometric knee extension strength in one randomized placebo-controlled, double-blind trial and increased mean knee extensor strength in one cross-sectional study. Tibolone also increased the lean body mass and decreased the accumulation of body fat.

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