4 is ideaal ... zelf neem ik er 6. Gewoon omdat Dorian het zegt
Clin. Sci. (Lond) 2011 Apr 19. [Epub ahead of print]
Omega 3 polyunsaturated fatty acids augment the muscle protein anabolic response to
hyperaminoacidemia-hyperinsulinemia in healthy young and middle aged men and women.
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B.
Abstract
Increased dietary long-chain n-3 polyunsaturated fatty acid (LCn-3PUFA)
intake stimulates muscle protein anabolism in individuals who experience
muscle loss due to aging or cancer cachexia. However, it is not known
hether LCn-3PUFA elicit similar anabolic effects in healthy individuals. To
answer this question we evaluated the effect of 8 weeks of LCn-3PUFA
supplementation (4 g·d-1 of Lovaza®) in nine 25-45 y old healthy subjects
on the rate of muscle protein synthesis (by using stable isotope labelled
tracer techniques) and the activation (phosphorylation) of elements of the
mTOR-p70s6k pathway during basal, postabsorptive conditions and during a
hyperinsulinemic-hyperaminoacidemic clamp. We also measured the
concentrations of protein, RNA, and DNA in muscle to obtain indices of the
protein synthetic capacity, translational efficiency and cell size. Neither the
basal muscle protein fractional synthesis rate nor basal signalling element
phosphorylation changed in response to LCn-3PUFA supplementation but the
anabolic response to insulin and amino acid infusion was greater after
LCn-3PUFA (i.e., the muscle protein fractional synthesis rate during insulin
and amino acid infusion increased from 0.062 * 0.004 to 0.083 * 0.007 %·h-1
and the phospho mTORSer2448 and p70s6kThr389 concentrations increased
by ~50%; all P < 0.05). In addition, the muscle protein concentration and
the protein-to-DNA ratio (i.e., muscle cell size) were both greater (P < 0.05)
after LCn-3PUFA supplementation. We conclude that LCn-3PUFA have
anabolic properties in healthy young and middle aged adults.
en noten zijn dus enkel nodig alleen een extratje voor je voedingschema kwa khal toch?
begrijp er geen k*t van..;p
