- Lid sinds
- 26 mei 2011
- Berichten
- 1.151
- Waardering
- 42
Overeem positief getest op verhoogde testosteronwaardes
- Topic starter wesleyutrecht
- Startdatum
- Recente activiteit Recente activiteit:
- Reacties 432
- Weergaven 35.080
- Volgers 48
-
- Tags
- testosteron
22Jarige
Cool Novice
- Lid sinds
- 30 sep 2003
- Berichten
- 231
- Waardering
- 1
- Lengte
- 2m02
Een ontstekingsremmer met testosteron erin... ik heb er iig nog nooit van gehoord. Waarom geen naam van het medicijn noemen? Elk bijsluiter/medicijn staat op internet tegenwoordig. Corticosteroïden zijn heel iets anders Zoals anderen zeggen: een slechter excuus dan trt, maar hoop wel dat hij ermee weg komt.
Jammer dat er geen vrije testosteron bloedwaarden getest is, zo kon je veel aannemelijker maken of zijn test verhoging zou kunnen door een toevoeging in een medicijn, als je al bedenkt hoeveel normale trt pure testosteron gel je moet smeren om in de buurt te komen van een waarde die ook echt buiten proporties is...
Jammer dat er geen vrije testosteron bloedwaarden getest is, zo kon je veel aannemelijker maken of zijn test verhoging zou kunnen door een toevoeging in een medicijn, als je al bedenkt hoeveel normale trt pure testosteron gel je moet smeren om in de buurt te komen van een waarde die ook echt buiten proporties is...
22Jarige
Cool Novice
- Lid sinds
- 30 sep 2003
- Berichten
- 231
- Waardering
- 1
- Lengte
- 2m02
Via sherdog forum
Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation.
Sten T, Finel M, Ask B, Rane A, Ekström L.
Source
Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Abstract
"Testosterone and epitestosterone are secreted mainly as glucuronide metabolites and the urinary ratio of testosterone glucuronide to epitestosterone glucuronide, often called T/E, serves as a marker for possible anabolic steroids abuse by athletes. UDP-glucuronosyltransferase (UGT) 2B17 is the most important catalyst of testosterone glucuronidation. The T/E might be affected by drugs that interact with UGT2B17, or other enzymes that contribute to testosterone glucuronidation. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used by sportsmen and we have examined the effect of two NSAIDs, diclofenac and ibuprofen, on testosterone and epitestosterone glucuronidation in human liver microsomes. In parallel, we have studied the inhibitory effect of these NSAIDs on recombinant UGT2B17 and UGT2B15, as well as other human hepatic UGTs that revealed low but detectable testosterone glucuronidation activity, namely UGT1A3, UGT1A4, UGT1A9 and UGT2B7. Both diclofenac and ibuprofen inhibited testosterone glucuronidation in microsomes, as well as UGT2B15 and UGT2B17. Interestingly, UGT2B15 was more sensitive than UGT2B17 to the two drugs, particularly to ibuprofen. Human liver microsomes lacking functional UGT2B17 exhibited significantly higher sensitivity to ibuprofen, suggesting that UGT2B15 plays a major role in the residual testosterone glucuronidation activity in UGT2B17-deficient individuals. Nonetheless, a minor contribution of other UGTs, particularly UGT1A9, to testosterone glucuronidation in such individuals cannot be ruled out at this stage. The epitestosterone glucuronidation activity of human liver microsomes was largely insensitive to ibuprofen and diclofenac. Taken together, the results highlight potential interactions between NSAIDs and androgen glucuronidation with possible implications for the validity of doping tests."
Enjoy.
Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation.
Sten T, Finel M, Ask B, Rane A, Ekström L.
Source
Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Abstract
"Testosterone and epitestosterone are secreted mainly as glucuronide metabolites and the urinary ratio of testosterone glucuronide to epitestosterone glucuronide, often called T/E, serves as a marker for possible anabolic steroids abuse by athletes. UDP-glucuronosyltransferase (UGT) 2B17 is the most important catalyst of testosterone glucuronidation. The T/E might be affected by drugs that interact with UGT2B17, or other enzymes that contribute to testosterone glucuronidation. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used by sportsmen and we have examined the effect of two NSAIDs, diclofenac and ibuprofen, on testosterone and epitestosterone glucuronidation in human liver microsomes. In parallel, we have studied the inhibitory effect of these NSAIDs on recombinant UGT2B17 and UGT2B15, as well as other human hepatic UGTs that revealed low but detectable testosterone glucuronidation activity, namely UGT1A3, UGT1A4, UGT1A9 and UGT2B7. Both diclofenac and ibuprofen inhibited testosterone glucuronidation in microsomes, as well as UGT2B15 and UGT2B17. Interestingly, UGT2B15 was more sensitive than UGT2B17 to the two drugs, particularly to ibuprofen. Human liver microsomes lacking functional UGT2B17 exhibited significantly higher sensitivity to ibuprofen, suggesting that UGT2B15 plays a major role in the residual testosterone glucuronidation activity in UGT2B17-deficient individuals. Nonetheless, a minor contribution of other UGTs, particularly UGT1A9, to testosterone glucuronidation in such individuals cannot be ruled out at this stage. The epitestosterone glucuronidation activity of human liver microsomes was largely insensitive to ibuprofen and diclofenac. Taken together, the results highlight potential interactions between NSAIDs and androgen glucuronidation with possible implications for the validity of doping tests."
Enjoy.
Galen
Peter Bond
Super Mod
Elite Member
15 jaar lid
Supplementen
Anabolen
Technologie
Wetenschap
10.000 likes
10.000 berichten
- Lid sinds
- 8 okt 2010
- Berichten
- 33.791
- Waardering
- 22.777
- Lengte
- 1m96
- Massa
- 102kg
- Vetpercentage
- 11%
Helemaal correct.
Al wou ik je er niet echt mee 'pakken'.Kwam hier via elite spy, dus had niet echt door waar het topic over ging toen ik op je reactie reageerde.
Laatst bewerkt:
Barteh
Dutch Bodybuilder
- Lid sinds
- 10 mrt 2010
- Berichten
- 529
- Waardering
- 33
- Lid sinds
- 28 aug 2005
- Berichten
- 17.882
- Waardering
- 3.426
- Lengte
- 1m97
- Massa
- 107kg
- Vetpercentage
- 13%
elite spy?
is dat zo'n functie in het elite forum waarmee je ons niet tot het elektronische BB-nirvana verlichte paupers kan in het oog houden?
- Lid sinds
- 28 aug 2005
- Berichten
- 17.882
- Waardering
- 3.426
- Lengte
- 1m97
- Massa
- 107kg
- Vetpercentage
- 13%
leuk, maar daar is de buffer van 6:1(of 4:1, want blijkbaar volgt Nevada commision niet de wada-code waar het die 4:1 is) test:epitest voor ipv 1:1. Om mogelijke false positives eruit te halen.
En de false negatives die je ermee creert zullen er meer zijn.
Laatst bewerkt:
Galen
Peter Bond
Super Mod
Elite Member
15 jaar lid
Supplementen
Anabolen
Technologie
Wetenschap
10.000 likes
10.000 berichten
- Lid sinds
- 8 okt 2010
- Berichten
- 33.791
- Waardering
- 22.777
- Lengte
- 1m96
- Massa
- 102kg
- Vetpercentage
- 11%
bertone10
Cool Novice
- Lid sinds
- 12 feb 2011
- Berichten
- 102
- Waardering
- 3
- Lengte
- 1m85
- Massa
- 88kg
- Vetpercentage
- 18%
NSAC vote decides on Alistair Overeem's continuation request
by Steven Marrocco on Apr 23, 2012 at 7:30 pm ET
The Nevada State Athletic Commission will on Tuesday vote whether Alistair Overeem gets additional time to gather support for his recent claim that a doctor-prescribed anti-flammatory caused him to fail a pre-fight drug test, or if a vote on his current license request is already in order.
"My assumption is that he'll need to explain why he needs a continuance," NSAC executive director Keith Kizer today told MMAjunkie.com (www.mmajunkie.com).
If the five-member commission votes to grant him one, the entire matter will be pushed to an NSAC meeting in summer, Kizer said, and Overeem will be restricted from fighting professionally.
Overeem, who will testify alongside the doctor who gave him the anti-flammatory drug, isn't guaranteed a continuance. Kizer said the commission borrowed from Nevada's gaming laws in requiring a vote to delay. NSAC Chairman Raymond "Skip" Avansino initially requested Overeem to appear at the April 24 meeting, which takes place in Las Vegas.
If Overeem is denied a continuance, he's likely to answer then for the failed drug test that sacked his title fight with Junior Dos Santos at UFC 146, which takes place May 26 at MGM Grand Garden Arena in Las Vegas. The pre-fight drug test was one of two random tests he was required to complete to fulfill the terms of a conditional license he received to fight Brock Lesnar at UFC 141. Earlier this month, UFC officials submitted a license application on behalf of Overeem for UFC 146.
Because Overeem is not currently licensed, he does not face an immediate suspension and/or fine. However, the NSAC could deny his license or sanction him in other ways if they determine he is at fault for the failed test.
This morning, Overeem broke his silence about his red flag, stating he was "completely unaware" that the drug he took allegedly contained testosterone, but admitting responsibility for using it to treat a rib injury that he said he suffered prior to the test that ensnared him with the commission.
"Although I was unaware, I do realize it is my job to know what I am putting into my body," he said. "I respect the Nevada commissioners and Executive Director Keith Kizer and what they are doing to keep the sport of mixed martial arts regulated and safe for athletes. I look forward to working with them in the days and weeks ahead."
It was at that media gathering on March 27 that Overeem and five other heavyweights scheduled to compete at UFC 146 were tested for performance-enhancing drugs and drugs of abuse. One test measuring the testosterone-to-epitestosterone (T/E) ratio of the athletes found that Overeem had a 14-to-1 ratio, more than twice the 6-to-1 ratio allowed by the NSAC.
"If the drug contained testosterone, it should have been known," said Don Caitlin, founder of the UCLA Olympic Analytical Lab. "And it should have been labeled. It's illegal to give injections of materials that contain testosterone in them unless it's a licensed doctor who knows that he's giving testosterone. But the world is full of doctors who are really not familiar with drugs in sports, and I've known many cases over the years where they have given drugs that were on the banned list without knowing what the banned list is or was.
"It's less and less acceptable to agree that the doctor made a mistake. OK, he made a mistake, but he's caused a great problem for his patient."
Bron: www.mmajunkie.com
by Steven Marrocco on Apr 23, 2012 at 7:30 pm ET
The Nevada State Athletic Commission will on Tuesday vote whether Alistair Overeem gets additional time to gather support for his recent claim that a doctor-prescribed anti-flammatory caused him to fail a pre-fight drug test, or if a vote on his current license request is already in order.
"My assumption is that he'll need to explain why he needs a continuance," NSAC executive director Keith Kizer today told MMAjunkie.com (www.mmajunkie.com).
If the five-member commission votes to grant him one, the entire matter will be pushed to an NSAC meeting in summer, Kizer said, and Overeem will be restricted from fighting professionally.
Overeem, who will testify alongside the doctor who gave him the anti-flammatory drug, isn't guaranteed a continuance. Kizer said the commission borrowed from Nevada's gaming laws in requiring a vote to delay. NSAC Chairman Raymond "Skip" Avansino initially requested Overeem to appear at the April 24 meeting, which takes place in Las Vegas.
If Overeem is denied a continuance, he's likely to answer then for the failed drug test that sacked his title fight with Junior Dos Santos at UFC 146, which takes place May 26 at MGM Grand Garden Arena in Las Vegas. The pre-fight drug test was one of two random tests he was required to complete to fulfill the terms of a conditional license he received to fight Brock Lesnar at UFC 141. Earlier this month, UFC officials submitted a license application on behalf of Overeem for UFC 146.
Because Overeem is not currently licensed, he does not face an immediate suspension and/or fine. However, the NSAC could deny his license or sanction him in other ways if they determine he is at fault for the failed test.
This morning, Overeem broke his silence about his red flag, stating he was "completely unaware" that the drug he took allegedly contained testosterone, but admitting responsibility for using it to treat a rib injury that he said he suffered prior to the test that ensnared him with the commission.
"Although I was unaware, I do realize it is my job to know what I am putting into my body," he said. "I respect the Nevada commissioners and Executive Director Keith Kizer and what they are doing to keep the sport of mixed martial arts regulated and safe for athletes. I look forward to working with them in the days and weeks ahead."
It was at that media gathering on March 27 that Overeem and five other heavyweights scheduled to compete at UFC 146 were tested for performance-enhancing drugs and drugs of abuse. One test measuring the testosterone-to-epitestosterone (T/E) ratio of the athletes found that Overeem had a 14-to-1 ratio, more than twice the 6-to-1 ratio allowed by the NSAC.
"If the drug contained testosterone, it should have been known," said Don Caitlin, founder of the UCLA Olympic Analytical Lab. "And it should have been labeled. It's illegal to give injections of materials that contain testosterone in them unless it's a licensed doctor who knows that he's giving testosterone. But the world is full of doctors who are really not familiar with drugs in sports, and I've known many cases over the years where they have given drugs that were on the banned list without knowing what the banned list is or was.
"It's less and less acceptable to agree that the doctor made a mistake. OK, he made a mistake, but he's caused a great problem for his patient."
Bron: www.mmajunkie.com
Sniezel
Freaky Bodybuilder
- Lid sinds
- 6 okt 2011
- Berichten
- 5.075
- Waardering
- 569
- Lengte
- 1m82
- Massa
- 95kg
- Vetpercentage
- 6%
- Lid sinds
- 7 jan 2011
- Berichten
- 818
- Waardering
- 53
- Lengte
- 1m80
- Massa
- 99kg
wesleyutrecht
Cool Novice
- Lid sinds
- 29 mrt 2012
- Berichten
- 108
- Waardering
- 5
- Lengte
- 1m84
- Massa
- 96kg
- Lid sinds
- 7 jan 2011
- Berichten
- 818
- Waardering
- 53
- Lengte
- 1m80
- Massa
- 99kg
Nog beter. Thanks.
wesleyutrecht
Cool Novice
- Lid sinds
- 29 mrt 2012
- Berichten
- 108
- Waardering
- 5
- Lengte
- 1m84
- Massa
- 96kg
BobbyV
Competitive Bodybuilder
- Lid sinds
- 2 sep 2011
- Berichten
- 2.488
- Waardering
- 205
- Lengte
- 1m91
- Massa
- 88kg
- Vetpercentage
- 15%
- Lid sinds
- 16 nov 2006
- Berichten
- 11.657
- Waardering
- 2.909
- Lengte
- 1m86
- Massa
- 102kg
Voor wie dit ook maar saaie kost vind om naar te kijken... https://twitter.com/#!/arielhelwani
---------- Post toegevoegd Tue 24 Apr 2012 om 20:00 ----------
Voor iemand die toch tegen iedereen heel stellig was dat de fight gewoon door ging, vind ik deze uitspraak van Kizer wel opmerkelijk.
Kizer says that after the 3/27 presser "Overeem speeded out of the building" before taking the drug test. They had to "get his ass" back
---------- Post toegevoegd Tue 24 Apr 2012 om 20:00 ----------
Voor iemand die toch tegen iedereen heel stellig was dat de fight gewoon door ging, vind ik deze uitspraak van Kizer wel opmerkelijk.
Kizer says that after the 3/27 presser "Overeem speeded out of the building" before taking the drug test. They had to "get his ass" back
- Lid sinds
- 7 jan 2011
- Berichten
- 818
- Waardering
- 53
- Lengte
- 1m80
- Massa
- 99kg
Begin er steeds minder vertrouwen in te hebben. Hij gaat geschorst worden.
TeamSjonnie
Competitive Bodybuilder
- Lid sinds
- 25 jul 2009
- Berichten
- 2.138
- Waardering
- 184
Er is verschil tussen spijt hebben en liegen. Hij liegt. Die n*ger zit aan de top en zwemt in het geld. Denk je dat ie spijt heeft ofzow.
- Lid sinds
- 16 nov 2006
- Berichten
- 11.657
- Waardering
- 2.909
- Lengte
- 1m86
- Massa
- 102kg
Ohja het is een forum dus dan kan alles lekker ongenuanceerd, wat denk je dat dit allemaal voor hem zelf doet?
tl21
Advanced Bodybuilder
- Lid sinds
- 21 apr 2006
- Berichten
- 1.228
- Waardering
- 18
- Lengte
- 1m92
- Massa
- 52kg
Volgens mij is hij een jaar geschorst.
http://www.ustream.tv/channel/overe...ign=t.co&utm_source=9947841&utm_medium=social
http://www.ustream.tv/channel/overe...ign=t.co&utm_source=9947841&utm_medium=social
Soortgelijke topics
