Van alle mogelijke bijwerkingen die je kunt hebben zijn de gevolgen van AAS gebruik voor het hart de meest zorgwekkende. Onderzoeken laten zien dat het eigenlijk niet uitmaakt welke aas je gebruikt maar dat er altijd sprake is schade aan hartcellen. De mate waarin en of dit tot gevolgen leidt kun je niet voorspellen maar er zijn gevallen bekend. Als er zich erfelijke problemen voordoen in zijn familie....tja ik hoef de zin eigenlijk niet af te maken als je enig gezond verstand hebt denk ik.
Sudden cardiac death during anabolic steroid abuse: morphologic and toxicologic findings in two fatal cases of bodybuilders
International Journal of Legal Medicine
January 2007, Volume 121, Issue 1, pp 48-53
Vittorio Fineschi, Irene Riezzo, Fabio Centini, Enrico Silingardi, Manuela Licata, Giovanni Beduschi, Steven B. Karch
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Abstract
We report two cases of sudden cardiac death (SCD) involving previously healthy bodybuilders who were chronic androgenic–anabolic steroids users. In both instances, autopsies, histology of the organs, and toxicologic screening were performed. Our findings support an emerging consensus that the effects of vigorous weight training, combined with anabolic steroid use and increased androgen sensitivity, may predispose these young men to myocardial injury and even SCD.
Cardiac Lesions Induced by Testosterone: Protective Effects of Dexrazoxane and Trimetazidine
Cardiovascular Toxicology
June 2009, Volume 9, Issue 2, pp 64-69
Dalila Belhani, Laurent Fanton, Fanny Vaillant, Jacques Descotes, Waheed Manati, Alain Tabib, Bernard Bui-Xuan, Quadiri Timour
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Abstract
Further to our previous observation of post-mortem cardiac lesions after sudden death in several athletes with a history of anabolic steroid abuse, this study was intended to reproduce these lesions in rabbits administered testosterone oenanthate, a prototypic anabolic steroid abused by athletes, and to provide evidence for the protective effects of trimetazidine and dexrazoxane that are used as antianginal and cardioprotective drugs, respectively. Groups of six rabbits each were administered saline, testosterone, or a combination of testosterone and either trimetazidine or dexrazoxane for 3 months. Histologic cardiac lesions including necrosis, misshapen cell nuclei, interstitial and endocardial fibrosis, lymphocytic infiltrates, and vascular dystrophies were observed in testosterone-treated rabbits. In contrast, no significant lesions were observed in the animals treated with testosterone combined with either trimetazidine or dexrazoxane. This is the first study providing evidence for testosterone cardiotoxicity following sub-chronic exposure in laboratory animals. In addition, these results suggest the protective role of trimetazidine and dexrazoxane.
De tekst in blauw is eigenlijk nog interessanter. Gebruik van trimetazidine of dexrazoxane beschermt het hart tijdens kuren. Dat eerste middel is wel te vinden op internet en het zou mij niet verbazen als menig prof een herhaal receptje hiervan heeft.