Sinds ik met HGH bezig ben herstel ik echt mega-snel PCT. Ook nooit meer last gehad van libidocrashes.
Ik had pas geleden nog een interessant artikel daarover gepost. Zal dat eens opzoeken.
---------- Toegevoegd om 08:57 ---------- De post hierboven werd geplaatst om 08:53 ----------
Peptides for testicular recovery
It’s a common practice these days for experienced bodybuilders to implement some dosage of IGF-1 either during or after a cycle to "pick up" a lagging body part, or to preserve gains in muscle. Growth Hormone (GH) is also a versatile drugd for cutting or bulking, with increasing popularity as it becomes more affordable. The value of IGF-1 and GH becomes so much more significant when we realize there integral role in testicular function. In fact, it seems that these hormones are more effective at building testes, than muscles.
Research has shown GH to be vitally important in testicular function, 95-97 but it is generally accepted that the beneficial effects are directly mediated by hGH’s conversion to IGF-1. As many of you know, IGF-1 is created in the liver by GH, upon interacting with insulin. So, we will be focusing on the usage and benefits of IGF-1, rather than GH, as it seems more cost effective and directly related to our purpose of optimizing recovery.
In short, IGF-1 increases steroidogenic acute regulatory protein (sTAR),98 and cholesterol side chain cleaving enzyme (CYP 11A)99. These are both rate-limiting steps and are critical factors for converting cholesterol into hormones, such as testosterone. IGF-1 also has the ability to increase the concentration of steroidogenic enzymes in the testes, such as 3b HSD.100 IGF-1 can also increase the testes sensitivity to LH and hCG by increasing the number of LH receptors.99-102
These positive effects on testicular function make IGF-1 an ideal drug for PCT. A dose of IGF-1 Lr3 at 80mcg/day, split two times per day, would likely be the most cost effective dose.
In conclusion, we have learned that utilizing hCG during a steroid cycle will significantly prevent testicular degeneration. This helps create a seamless transition from "on cycle" to "off cycle". Then, by avoiding the deleterious SERMs such Clomid and Nolvadex and opting for safer alternatives, you can seemingly avoid any sort of post cycle crash, while maintaining a strong libido and uncompromised emotional health.
References
95. Hereditary isolated somatropin deficiency: effects of human growth hormone adrninistration.
Sheikholislan BM, Stempfel RS 1972
Pediatrics 49:362-374
96. The effects of growth hormone on the Leydig cell response to chorionic gonadotropin in boys with hypopituitarism.
Kulin HE, Samdjlike E, Santen R, Santner S 1981
Clin Endocrinol (Oxf) 45:468-472
97. Testicular function in hypopituitarism.
Rivarola MA, et al
Pediatr Res 6:634-641 (1972)
98. Leydig cells: endocrine, paracrine, and autocrine regulation.
Saez JM
Endocr Rev 15:574–626 (1994)
99. Molecular Mechanisms of Insulin-like Growth Factor-I Mediated Regulation of the Steroidogenic Acute Regulatory Protein in Mouse Leydig Cells
Pulak R. Manna, et al
Mol. Endocrinol., Feb 2006; 20: 362 - 378.
100. Regulation of steroidogenic genes by insulin-like growth factor-1 and follicle-stimulating hormone: differential responses of cytochrome P450 side-chain cleavage, steroidogenic acute regulatory protein, and 3*-hydroxysteroid dehydrogenase/isomerase in rat granulosa cells. Eimerl S, Orly J . Biol Reprod 67:900–910 (2002)
101. Insulin-like growth factor-I-mediated amplification of follicle-stimulating hormone-supported progesterone accumulation by cultured rat granulosa cells: enhancement of steroidogenic enzyme activity and expression. deMoura MD, Choi D, Adashi EY, Payne DW. Biol Reprod 56:946–953 (1997)
102. Upregulation of human chorionic gonadotrophin-induced steroidogenic acute